{"id":12355,"date":"2024-03-21T16:39:06","date_gmt":"2024-03-21T15:39:06","guid":{"rendered":"https:\/\/kaks.hb-dev.de\/about-us\/what-we-do\/research\/"},"modified":"2024-09-27T15:31:06","modified_gmt":"2024-09-27T13:31:06","slug":"research","status":"publish","type":"page","link":"https:\/\/kinderaugenkrebsstiftung.de\/en\/about-us\/what-we-do\/research\/","title":{"rendered":"Research"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"12355\" class=\"elementor elementor-12355 elementor-4821\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-dbe3009 e-flex e-con-boxed e-con e-parent\" data-id=\"dbe3009\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f0d55b0 elementor--h-position-center elementor--v-position-middle elementor-widget elementor-widget-slides\" data-id=\"f0d55b0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;navigation&quot;:&quot;none&quot;,&quot;transition&quot;:&quot;fade&quot;,&quot;transition_speed&quot;:1500,&quot;autoplay&quot;:&quot;yes&quot;,&quot;pause_on_hover&quot;:&quot;yes&quot;,&quot;pause_on_interaction&quot;:&quot;yes&quot;,&quot;autoplay_speed&quot;:5000,&quot;infinite&quot;:&quot;yes&quot;}\" data-widget_type=\"slides.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-swiper\">\n\t\t\t\t\t<div class=\"elementor-slides-wrapper elementor-main-swiper swiper\" role=\"region\" aria-roledescription=\"carousel\" aria-label=\"Slides\" dir=\"ltr\" data-animation=\"\">\n\t\t\t\t<div class=\"swiper-wrapper elementor-slides\">\n\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-repeater-item-463bfff swiper-slide\" role=\"group\" aria-roledescription=\"slide\"><div class=\"swiper-slide-bg\" role=\"img\" aria-label=\"Forschung Kinderaugenkrebs Header\"><\/div><div class=\"swiper-slide-inner\" ><div class=\"swiper-slide-contents\"><\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3e0149b e-flex e-con-boxed e-con e-child\" data-id=\"3e0149b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;position&quot;:&quot;absolute&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-1ad1ec5 e-con-full e-flex elementor-invisible e-con e-child\" data-id=\"1ad1ec5\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeInUp&quot;,&quot;animation_delay&quot;:500,&quot;animation_mobile&quot;:&quot;fadeIn&quot;,&quot;animation_mobile_extra&quot;:&quot;fadeIn&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ced2efd e-con-full e-flex e-con e-child\" data-id=\"ced2efd\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div data-ha-element-link=\"{&quot;url&quot;:&quot;#scrolldown&quot;,&quot;is_external&quot;:&quot;&quot;,&quot;nofollow&quot;:&quot;&quot;}\" style=\"cursor: pointer\" class=\"elementor-element elementor-element-ead5807 elementor-widget elementor-widget-html\" data-id=\"ead5807\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"scroll-downs\">\n  <div class=\"mousey\">\n    <div class=\"scroller\"><\/div>\n  <\/div>\n<\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4bcb4b8e e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"4bcb4b8e\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cfba523 elementor-widget elementor-widget-ha-breadcrumbs happy-addon ha-breadcrumbs happy-addon-pro\" data-id=\"cfba523\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"ha-breadcrumbs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<ul class=\"ha-breadcrumbs\"><li class=\"ha-breadcrumbs-item ha-breadcrumbs-start\"><a href=\"https:\/\/kinderaugenkrebsstiftung.de\/en\/\" rel=\"home\"><span class=\"ha-breadcrumbs-text\"><span class=\"ha-breadcrumbs-home-icon\"><span class=\"fas fa-home\" aria-hidden=\"true\"><\/span><\/span><\/span><\/a><\/li><\/ul>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-563383b2 e-flex e-con-boxed e-con e-parent\" data-id=\"563383b2\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-d34132f e-con-full e-flex e-con e-child\" data-id=\"d34132f\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5a14f801 elementor-widget elementor-widget-spacer\" data-id=\"5a14f801\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4d03624a elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"4d03624a\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Research<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-54a0dffa e-con-full e-flex e-con e-child\" data-id=\"54a0dffa\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7dbf9887 elementor-widget elementor-widget-spacer\" data-id=\"7dbf9887\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-27ce35dc elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"27ce35dc\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Research into the mechanisms and possible therapeutics for retinoblastoma not only benefits retinoblastoma children, but has great potential to serve as a basis for all cancers.<\/strong><\/p>\n<p>&#8220;When the final history of cancer research is one day written, retinoblastoma will deserve its own chapter. Studies of this rare childhood tumor have yielded the first widely accepted tumor progression model, the first cloned tumor suppressor gene, and several other firsts in basic cancer research.&#8221; (from Journal of the National Cancer Institute, Vol. 96, No. 15, August 4, 2004)<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5438227a elementor-hidden-mobile_extra elementor-hidden-mobile e-flex e-con-boxed e-con e-parent\" data-id=\"5438227a\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;sticky&quot;:&quot;top&quot;,&quot;_ha_eqh_enable&quot;:false,&quot;sticky_on&quot;:[&quot;desktop&quot;,&quot;laptop&quot;,&quot;tablet_extra&quot;,&quot;tablet&quot;,&quot;mobile_extra&quot;,&quot;mobile&quot;],&quot;sticky_offset&quot;:0,&quot;sticky_effects_offset&quot;:0,&quot;sticky_anchor_link_offset&quot;:0}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-1adebf46 e-con-full e-flex e-con e-child\" data-id=\"1adebf46\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-386e82d8 elementor-align-right elementor-hidden-mobile elementor-hidden-mobile_extra elementor-invisible elementor-widget elementor-widget-button\" data-id=\"386e82d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInRight&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#mission\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Mission<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9309dfe elementor-align-right elementor-hidden-mobile elementor-hidden-mobile_extra elementor-invisible elementor-widget elementor-widget-button\" data-id=\"9309dfe\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInRight&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#publikationen\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Publications<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4629316f elementor-align-right elementor-hidden-mobile elementor-hidden-mobile_extra elementor-invisible elementor-widget elementor-widget-button\" data-id=\"4629316f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInRight&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#forschungsprojekte\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Research projects<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4ed59e78 elementor-align-right elementor-hidden-mobile elementor-hidden-mobile_extra elementor-invisible elementor-widget elementor-widget-button\" data-id=\"4ed59e78\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInRight&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#projektfoerderung\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Project funding<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3dbfcb4b elementor-align-right elementor-hidden-mobile elementor-hidden-mobile_extra elementor-invisible elementor-widget elementor-widget-button\" data-id=\"3dbfcb4b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInRight&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#forschungspartner\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Research partners<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7e3b382d e-flex e-con-boxed e-con e-parent\" data-id=\"7e3b382d\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4ffb4dbe elementor-widget-divider--view-line elementor-invisible elementor-widget elementor-widget-divider\" data-id=\"4ffb4dbe\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span 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-9.7-15.554 18.835 18.835 0 0 1 1.3-15.4\" fill=\"#fff\"><\/path><\/g><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a1f2968 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"a1f2968\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Prof. Dr. med. Vinodh Kakkassery, Chief Physician at Chemnitz Hospital<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1ceecbfa elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"1ceecbfa\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>&#8220;The KAKS is: Good. Exciting. Courageous. Perhaps the latter is what makes it special. I see the courage of KAKS to believe in research, to invest in retinoblastoma research. To invest money, time and love. Research and medicine are often far removed from people, alien, incomprehensible. KAKS goes right into that.&#8221;<\/strong><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5e054bcd elementor-widget elementor-widget-spacer\" data-id=\"5e054bcd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2ba400c e-con-full e-flex e-con e-child\" data-id=\"2ba400c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6dc98df2 elementor-align-left elementor-invisible elementor-widget elementor-widget-button\" data-id=\"6dc98df2\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-lg\" href=\"https:\/\/kinderaugenkrebsstiftung.de\/en\/an-interview-with-prof-dr-med-vinodh-kakkassery-chief-physician-at-chemnitz-hospital\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"hm hm-arrow-right1\"><\/i>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Learn more<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-45874f68 e-flex e-con-boxed e-con e-parent\" data-id=\"45874f68\" data-element_type=\"container\" data-e-type=\"container\" id=\"mission\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-43e061e0 e-con-full e-flex e-con e-child\" data-id=\"43e061e0\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3576d78f elementor-widget elementor-widget-spacer\" data-id=\"3576d78f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1069caed elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"1069caed\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Mission <br> of KAKS<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-962c220 e-con-full e-flex e-con e-child\" data-id=\"962c220\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-127ace0c elementor-widget elementor-widget-spacer\" data-id=\"127ace0c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-415733a5 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"415733a5\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>In contrast to other cancers, there has been little research into molecular biological therapies for retinoblastoma for a long time.<br \/>\nThe reason: retinoblastoma is a rare disease and there is no commercial interest. <\/p>\n<p><strong>The Children&#8217;s Eye Cancer Foundation has changed this and enables young doctors in particular to carry out research in this field and has now initiated, supported and completed various research projects &#8211; each in search of new therapies, diagnostic methods or aftercare and early detection.<br \/>\nAll this in cooperation with university hospitals throughout Europe. <\/strong><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-63ee0057 elementor-invisible elementor-widget elementor-widget-ha-unfold happy-addon ha-unfold happy-addon-pro\" data-id=\"63ee0057\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;fold_height&quot;:1,&quot;unfold_text&quot;:&quot;Read more&quot;,&quot;unfold_icon&quot;:{&quot;value&quot;:&quot;hm hm-plus-open&quot;,&quot;library&quot;:&quot;happy-icons&quot;},&quot;fold_text&quot;:&quot;read less&quot;,&quot;fold_icon&quot;:{&quot;value&quot;:&quot;hm hm-minus-large&quot;,&quot;library&quot;:&quot;happy-icons&quot;},&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;trigger&quot;:&quot;click&quot;,&quot;transition_duration&quot;:500}\" data-widget_type=\"ha-unfold.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"ha-unfold-widget-wrapper ha-unfold-direction-below\">\n\t\t\t\t\t\t\t<h3 class=\"ha-unfold-heading\">KAKS has been particularly successful to date on three levels<\/h3>\t\t\t\t\t\t<div class=\"ha-unfold-data\">\n\t\t\t\t<div class=\"ha-unfold-data-render\">\n\t\t\t\t\t\t\t<div data-elementor-type=\"section\" data-elementor-id=\"12085\" class=\"elementor elementor-12085 elementor-4970 elementor-4970\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\" data-elementor-post-type=\"elementor_library\">\n\t\t\t<div class=\"elementor-element elementor-element-b866daa e-flex e-con-boxed e-con e-parent\" data-id=\"b866daa\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9b7182d elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"9b7182d\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>1. <\/strong><br \/>Therapeutic and diagnostic approaches for retinoblastoma that originate from successfully completed or ongoing studies of other types of cancer (see e.g. CAR-T cell project).<\/p>\n<p><strong>2.<\/strong><br \/>Projects that are promising but still too small for the big pots (e.g. DFG, DKS, EU).<\/p>\n<p><strong>3. <\/strong><br \/>Projects that cannot wait for long approval procedures.<br \/>\nThese are examined by KAKS at short notice and, if approved by the reviewers, receive interim funding.<br \/>\nVarious KAKS projects have laid the foundations for major German and EU studies.  <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-64c9c4a elementor-widget elementor-widget-spacer\" data-id=\"64c9c4a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9b8faf6 elementor-align-left elementor-invisible elementor-widget elementor-widget-button\" data-id=\"9b8faf6\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#projektfoerderung\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Project funding<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e05c1e7 elementor-widget elementor-widget-spacer\" data-id=\"e05c1e7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<button class=\"ha-unfold-btn ha-unfold-icon-after\">\n\t\t\t\t\t<i aria-hidden=\"true\" class=\"hm hm-plus-open\"><\/i>\t\t\t\t\t\t\t\t\t\t\t<span>Read more<\/span>\n\t\t\t\t\t\t\t\t\t<\/button>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2dcbf61 e-flex e-con-boxed e-con e-parent\" data-id=\"2dcbf61\" data-element_type=\"container\" data-e-type=\"container\" id=\"publikationen\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-0ac35f8 e-con-full e-flex e-con e-child\" data-id=\"0ac35f8\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f6b997a elementor-widget elementor-widget-spacer\" data-id=\"f6b997a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5faaf94 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"5faaf94\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">PUBLICATIONS<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0af042b elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"0af042b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Here you will find an overview of the publications that have emerged from Kaks research.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3fca192 e-con-full e-flex e-con e-child\" data-id=\"3fca192\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-710caa2 elementor-widget elementor-widget-spacer\" data-id=\"710caa2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4885040 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"4885040\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<strong>Origin of Rb: single-cell RNA sequencing<\/strong> Overview of a typical RNA-Seq workflow Griffith et al.\ndoi: <a href=\"https:\/\/journals.plos.org\/ploscompbiol\/article?id=10.1371\/journal.pcbi.1004393\" target=\"_blank\" rel=\"noopener\">https:\/\/journals.plos.org\/ploscompbiol\/article?id=10.1371\/journal.pcbi.1004393<\/a> \t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f1e38c5 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"f1e38c5\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<strong>Combating chemoresistance<\/strong><a href=\"https:\/\/www.proteomicscenter.nl\/background-information\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.proteomicscenter.nl\/background-information\/<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-72f8894 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"72f8894\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<strong>Zebrafish as an Orthotopic Tumor Model for Retinoblastoma \/ Mimicking Routes of Human Metastasis<\/strong><a href=\"https:\/\/doi.org\/10.3390\/cancers14235814\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3390\/\u00adcancers14235814<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-74be274 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"74be274\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<strong>Adjuvant therapy for children treated by enucleation at diagnosis of retinoblastoma<\/strong><a href=\"https:\/\/doi.org\/10.1016\/j.ejcped.2023.100004\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/\u00adj.ejcped.2023.100004<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1176e58 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"1176e58\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<strong>Use of CAR-T cells in retinoblastoma<\/strong><a href=\"https:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/s12885-019-6131-1\" target=\"_blank\" rel=\"noopener\">https:\/\/bmccancer.\u00adbiomedcentral.com\/articles\/\u00ad10.1186\/s12885-019-6131-1<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-71905d9 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"71905d9\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Gene analysis of retinal organoids<\/strong><br \/><a href=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/06\/Schipper_et_al_Generation_hESC_H9_sublines.pdf\" target=\"_blank\" rel=\"noopener\">PDF for download<\/a><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a064583 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"a064583\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Tumor marker development &#8211; Liquid Biopsy &#8211; Early diagnosis \/ EU project<\/strong><br \/><a href=\"https:\/\/www.cell.com\/cancer-cell\/fulltext\/S1535-6108(15)00349-9\" target=\"_blank\" rel=\"noopener\">https:\/\/www.cell.com\/cancer-cell\/fulltext\/S1535-6108(15)00349-9<\/a><br \/><a href=\"https:\/\/www.gesundheitsforschung-bmbf.de\/de\/nirbtest-8466.php\" target=\"_blank\" rel=\"noopener\">https:\/\/www.gesundheitsforschung-bmbf.de\/de\/nirbtest-8466.php<\/a><br \/><a href=\"https:\/\/www.gesundheitsforschung-bmbf.de\/de\/era-net-transcan-3413.php\" target=\"_blank\" rel=\"noopener\">https:\/\/www.gesundheitsforschung-bmbf.de\/de\/era-net-transcan-3413.php<\/a><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1072dd9 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"1072dd9\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Diagnostic pathway recognition<\/strong><br \/><a href=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/06\/WilmDGKJ2013pdf.pdf\" target=\"_blank\" rel=\"noopener\">Analysis of the diagnostic pathway in children with retinoblastoma to improve early detection<\/a><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d9842fd elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"d9842fd\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<strong>Prevention of radiotherapy induced secondary tumors<\/strong><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27694105\" target=\"_blank\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27694105<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-788aadf elementor-invisible elementor-widget elementor-widget-image\" data-id=\"788aadf\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"460\" src=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/06\/KAKS-Publikationen.png\" class=\"attachment-large size-large wp-image-8749\" alt=\"\" srcset=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/06\/KAKS-Publikationen.png 945w, https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/06\/KAKS-Publikationen-300x172.png 300w, https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/06\/KAKS-Publikationen-768x441.png 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-542f0386 e-flex e-con-boxed e-con e-parent\" data-id=\"542f0386\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5a0476ca elementor-widget-divider--view-line elementor-invisible elementor-widget elementor-widget-divider\" data-id=\"5a0476ca\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5967ce0d e-flex e-con-boxed e-con e-parent\" data-id=\"5967ce0d\" data-element_type=\"container\" data-e-type=\"container\" id=\"forschungsprojekte\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-e872e6c e-con-full e-flex e-con e-child\" data-id=\"e872e6c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-698c2031 elementor-widget elementor-widget-spacer\" data-id=\"698c2031\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-43c0bd0c elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"43c0bd0c\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Research <br> projects<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1e711d45 e-con-full e-flex e-con e-child\" data-id=\"1e711d45\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2057c734 elementor-widget elementor-widget-spacer\" data-id=\"2057c734\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2177c1b0 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"2177c1b0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>We strive to continuously improve the care of retinoblastoma patients in the areas of early detection, therapy and aftercare.<br \/>\nSince 2010, the Children&#8217;s Eye Cancer Foundation has initiated and funded numerous research projects in cooperation with renowned research institutions. <br \/><strong>Here we present current projects and the results of previous projects.<\/strong><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d1b6da9 elementor-invisible elementor-widget elementor-widget-image\" data-id=\"d1b6da9\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"800\" height=\"460\" src=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/05\/KAKS-Forschungsprojekte.jpg\" class=\"attachment-large size-large wp-image-7862\" alt=\"\" srcset=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/05\/KAKS-Forschungsprojekte.jpg 945w, https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/05\/KAKS-Forschungsprojekte-300x172.jpg 300w, https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/05\/KAKS-Forschungsprojekte-768x441.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-803b27c elementor-invisible elementor-widget elementor-widget-n-accordion\" data-id=\"803b27c\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;default_state&quot;:&quot;all_collapsed&quot;,&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;max_items_expended&quot;:&quot;one&quot;,&quot;n_accordion_animation_duration&quot;:{&quot;unit&quot;:&quot;ms&quot;,&quot;size&quot;:400,&quot;sizes&quot;:[]}}\" data-widget_type=\"nested-accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"e-n-accordion\" aria-label=\"Accordion. Open links with Enter or Space, close with Escape, and navigate with Arrow Keys\">\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-1340\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"1\" tabindex=\"0\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-1340\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Origin of RB: Single-cell RNA sequencing <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><i aria-hidden=\"true\" class=\"hm hm-minus-large\"><\/i><\/span>\n\t\t\t<span class='e-closed'><i aria-hidden=\"true\" class=\"hm hm-plus-open\"><\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1340\" class=\"elementor-element elementor-element-f4364b6 e-con-full e-flex e-con e-child\" data-id=\"f4364b6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1340\" class=\"elementor-element elementor-element-0dce42c e-con-full e-flex e-con e-child\" data-id=\"0dce42c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-53ba3f5 elementor-widget elementor-widget-text-editor\" data-id=\"53ba3f5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Prof. Bornfeld, Prof. Lohmann<\/strong><br \/>KAKS is involved in funding this DKS study<br \/>The aim is to optimize long-term care and improve the long-term prognosis and quality of life.<br \/>\nTo this end, the long-term therapeutic consequences of the various forms of treatment were determined and the individual genetic disposition was also taken into account with regard to the risk of secondary tumors.<br \/>\nIn addition, adult patients and parents were informed about preventive measures.<br \/>\nChildren and adolescents were included in the first phase and adult patients in the second phase (collective of approx. 570 test subjects).   <\/p>\n<p>Status: The studies have been completed and the results are available.<br \/>\nThe results of the first phases have since been published (Temming et al. 2015, Pediatric Blood Cancer)<br \/>Funded by KAKS and the German Childhood Cancer Foundation. <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4ef0702 elementor-widget elementor-widget-text-editor\" data-id=\"4ef0702\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>University Hospital M\u00fcnster &#8211; PD Dr. Kornelius Kerl Group<\/strong><br \/>If retinoblastoma is diagnosed early, the spread of the disease is limited to the eye.<br \/>\nIf the retinoblastoma has already spread outside the eye, the children have an unfavorable prognosis despite intensive treatment.<br \/>\nChemotherapy is regularly carried out in such cases.<br \/>\nHowever, the cancer can also develop resistance to this therapy, so that certain cells survive.<br \/>\nLast year, Dr. Kornelius Kerl&#8217;s group at the University of M\u00fcnster, with the support of KAKS, used single-cell RNA sequencing to analyze which cancer cells survive chemotherapy.<br \/>\nSuch cells are responsible for the development of therapy resistance and relapses of the disease.<br \/>\nIn the course of this research project, the group was able to show that only very specific cell populations of these tumors respond to chemotherapy, while other retinoblastoma cells survive these therapies.<br \/>\nThis project has thus made it possible to characterize therapy-resistant tumour cell populations in retinoblastomas for the first time.<br \/>\nBased on this knowledge, future projects now aim to find out how therapy resistance can be overcome in order to be able to treat effectively when conventional chemotherapy does not respond.<br \/>\nFunded by the KAKS.         <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ac14da0 elementor-invisible elementor-widget elementor-widget-image\" data-id=\"ac14da0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"457\" src=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/06\/KAKS-EntstehungRB.jpg\" class=\"attachment-large size-large wp-image-8751\" alt=\"\" srcset=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/06\/KAKS-EntstehungRB.jpg 950w, https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/06\/KAKS-EntstehungRB-300x171.jpg 300w, https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/06\/KAKS-EntstehungRB-768x439.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d328979 elementor-widget elementor-widget-text-editor\" data-id=\"d328979\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Overview of a typical RNA-Seq workflow Griffith et al.<br \/>\ndoi: <a href=\"https:\/\/journals.plos.org\/ploscompbiol\/article?id=10.1371\/journal.pcbi.100439\" target=\"_blank\" rel=\"noopener\">https:\/\/journals.plos.org\/ploscompbiol\/article?id=10.1371\/journal.pcbi.1004393<\/a> <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-1341\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"2\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-1341\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Detection of minimal residual disease in patients with retinoblastoma <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><i aria-hidden=\"true\" class=\"hm hm-minus-large\"><\/i><\/span>\n\t\t\t<span class='e-closed'><i aria-hidden=\"true\" class=\"hm hm-plus-open\"><\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1341\" class=\"elementor-element elementor-element-7040e21 e-con-full e-flex e-con e-child\" data-id=\"7040e21\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1341\" class=\"elementor-element elementor-element-6dd948d e-con-full e-flex e-con e-child\" data-id=\"6dd948d\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e140c9f elementor-widget elementor-widget-text-editor\" data-id=\"e140c9f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>University Hospital Essen &#8211; Prof. Dr. Petra Ketteler et al.<\/strong><br \/>The gold standard for the detection of metastases is the cytological examination of bone marrow aspirates and cerebrospinal fluid, but the sensitivity is limited.<br \/>\nThe aim of this study is to establish a more sensitive method for detecting metastatic cells in blood, bone marrow<br \/>and cerebrospinal fluid.<br \/>\nTo this end, the marker CRX should be measured using real-time PCR (qPCR) and digital droplet PCR (ddPCR).<br \/>\nThe photoreceptor gene CRX can serve as a diagnostic marker for retinal tumors.<br \/>\nThe bone marrow and cerebrospinal fluid samples were cytologically evaluated by a pediatric hemato-oncologist and these results were correlated with the qPCR, ddPCR and clinical results.<br \/>\nThus, ddPCR for CRX was identified as a suitable method for the quantification of retinoblastoma cell lines.<br \/>\nThis should enable earlier detection of CRX expression in qPCR and ddPCR than in cytology.<br \/>This KAKS-funded research project was presented as a poster at the Research Day of the University of Duisburg Essen.      <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ceb5ffb elementor-invisible elementor-widget elementor-widget-image\" data-id=\"ceb5ffb\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"227\" src=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/06\/KAKS-Publikationen-02.jpg\" class=\"attachment-large size-large wp-image-8753\" alt=\"\" srcset=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/06\/KAKS-Publikationen-02.jpg 950w, https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/06\/KAKS-Publikationen-02-300x85.jpg 300w, https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/06\/KAKS-Publikationen-02-768x217.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f5148cf elementor-widget elementor-widget-text-editor\" data-id=\"f5148cf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em>Clinical and morphological images of a child with an extraorbital retino-blastoma.<br \/>\nA: MRI of the head (saggital) shows an intracranial tumor. <\/em><br \/><em>B: MRI of the spine shows metastasis.<br \/>\nC: Bone marrow smear shows small blue stained retinoblastoma cells lying together as a cluster. <\/em><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-1342\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"3\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-1342\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Combating chemoresistance <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><i aria-hidden=\"true\" class=\"hm hm-minus-large\"><\/i><\/span>\n\t\t\t<span class='e-closed'><i aria-hidden=\"true\" class=\"hm hm-plus-open\"><\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1342\" class=\"elementor-element elementor-element-78a0d03 e-con-full e-flex e-con e-child\" data-id=\"78a0d03\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1342\" class=\"elementor-element elementor-element-bb96cc2 e-con-full e-flex e-con e-child\" data-id=\"bb96cc2\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-13e123a elementor-widget elementor-widget-text-editor\" data-id=\"13e123a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>University Hospital L\u00fcbeck &#8211; Group PD Dr. rer.<br \/>\nnat.<br \/>\nVinodh Kakkassery  <\/strong><br \/>This project lays the foundation for the development of a switch for programmed cell death (apoptosis) in chemotherapy-resistant RB tumors by therapeutically inhibiting the switching enzymes (sphingokinases).<br \/>\nThe results to date can be found in the literature list on the website.<br \/>\nFurther publications are in preparation.  <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bd7f2a2 elementor-widget elementor-widget-text-editor\" data-id=\"bd7f2a2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>First, the role of sphingosine and sphingosine-1-phosphate as a signal for cell death and survival in the resistant retinoblastoma cells in cell culture was investigated and differences in the extracellular matrix between the resistant and therapy-sensitive cells were identified.<br \/>\nProteomics analysis was performed to investigate the protein level.<br \/>\nThe proteomics analysis revealed further differences between these two cells.<br \/>\nA particular focus of the working group was on the investigation of calcium channels and their response to various channel activators and inhibitors.<br \/>\nCurrently, another manuscript on this topic is almost finalized by the research group, which deals with the role of the nerve growth factor in the development of resistance of retinoblastoma in this cell model.<br \/>\nThese results were achieved with the support of the KAKS Foundation.<br \/>\nThe next step is to link up with the National Center for Tumor Diseases (www.nct-dresden.de) and the Oncoray Research Center (www.oncoray.de) in Dresden in order to achieve the final therapeutic research goal with these structures.<br \/>\nFunded by the KAKS.       <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-717e552 elementor-invisible elementor-widget elementor-widget-image\" data-id=\"717e552\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"457\" src=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/06\/KAKS-Publikationen-03.jpg\" class=\"attachment-large size-large wp-image-8755\" alt=\"\" srcset=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/06\/KAKS-Publikationen-03.jpg 950w, https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/06\/KAKS-Publikationen-03-300x171.jpg 300w, https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/06\/KAKS-Publikationen-03-768x439.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2d1a3c7 elementor-widget elementor-widget-text-editor\" data-id=\"2d1a3c7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em>Translation of 22,000 genes (genome) into the transcriptome (RNA) and subsequent expression into the proteome (protein), which can then be analyzed to see which genes are converted into proteins and in what form.<br \/>\nSource: <a href=\"https:\/\/www.proteomicscenter.nl\/background-information\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.proteomicscenter.nl\/background-information\/<\/a> <\/em><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-1343\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"4\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-1343\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Zebrafish as an Orthotopic Tumor Model for Retinoblastoma \/ Mimicking Routes of Human Metastasis <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><i aria-hidden=\"true\" class=\"hm hm-minus-large\"><\/i><\/span>\n\t\t\t<span class='e-closed'><i aria-hidden=\"true\" class=\"hm hm-plus-open\"><\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1343\" class=\"elementor-element elementor-element-95f033a e-con-full e-flex e-con e-child\" data-id=\"95f033a\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1343\" class=\"elementor-element elementor-element-d0ada04 e-con-full e-flex e-con e-child\" data-id=\"d0ada04\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a0e87fc elementor-widget elementor-widget-text-editor\" data-id=\"a0e87fc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<strong>Cooperation Universities of Essen, Bochum and M\u00fcnster<\/strong> The nature of the zebrafish enables the visualization of migrating cells in living juvenile fish under the microscope.\nThe aim of this study is to analyze the timing and metastatic pathways of different retinoblastoma cell lines.\nIn this zebrafish model, migrating retino-blastoma cells are found along the optic nerve and in adjacent regions of the brain, resembling the pattern of metastasis in human patients.\nThe zebrafish model should facilitate future pharmacological studies for the treatment of retinoblastoma.\nIn the study, three fluorescently labeled retinoblastoma cell lines were injected into the left eye of zebrafish.\nThe time to onset of migration and the routes for all three retinoblastoma cell lines were comparable and resulted in migration into the brain and ventricles of the forebrain, midbrain and hindbrain.\nThe study showed that the zebrafish eye is well suited for analyzing migration pathways in retinoblastoma and reflects well the patterns of retinoblastoma metastases in humans.\nWe have previously reported on the ongoing study This KAKS-funded project has been published: Cancers 2022, 14, 5814.         <em><a href=\"https:\/\/doi.org\/10.3390\/cancers14235814\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.3390\/\u00adcancers14235814<\/a><\/em>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-1344\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"5\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-1344\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Adjuvant therapy for children treated by enucleation at diagnosis of retinoblastoma <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><i aria-hidden=\"true\" class=\"hm hm-minus-large\"><\/i><\/span>\n\t\t\t<span class='e-closed'><i aria-hidden=\"true\" class=\"hm hm-plus-open\"><\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1344\" class=\"elementor-element elementor-element-6aecd45 e-con-full e-flex e-con e-child\" data-id=\"6aecd45\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1344\" class=\"elementor-element elementor-element-0c6d98c e-con-full e-flex e-con e-child\" data-id=\"0c6d98c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-76130a2 elementor-widget elementor-widget-text-editor\" data-id=\"76130a2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Consortium Universities of Essen, Berlin, Zurich, M\u00fcnster, Graz, T\u00fcbingen<\/strong><br \/>Retinoblastoma is often associated with misdiagnosis of clinical signs and lack of referral to a specialized retinoblastoma center.<br \/>\nPrecise molecular genetic biomarkers such as circulating tumor DNA for risk stratification may help to improve risk stratification, reduce side effects and ensure survival.<br \/>\nIn this prospective, multicenter observational study, data from 184 patients with retinoblastoma and primary enucleation were collected between 2013 and 2020.<br \/>\nThe study showed that primary enucleation alone and additional risk-stratified adjuvant chemotherapy lead to very high cure rates in most retinoblastoma patients.<br \/>The study was funded by the German Childhood Cancer Foundation and the Children&#8217;s Eye Cancer Foundation.<br \/>\nThis project was recently published: EJC Pediatric Oncology 1 (2023) 100004    <br \/><em><a href=\"https:\/\/doi.org\/10.1016\/j.ejcped.2023.100004\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1016\/j.ejcped.2023.100004<\/a><\/em><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-1345\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"6\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-1345\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Collaborative study to identify Biomarkers to adjust treatment intensity for children with Retinoblastoma (CoBioRB) <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><i aria-hidden=\"true\" class=\"hm hm-minus-large\"><\/i><\/span>\n\t\t\t<span class='e-closed'><i aria-hidden=\"true\" class=\"hm hm-plus-open\"><\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1345\" class=\"elementor-element elementor-element-93ff811 e-con-full e-flex e-con e-child\" data-id=\"93ff811\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1345\" class=\"elementor-element elementor-element-7bcfff3 e-con-full e-flex e-con e-child\" data-id=\"7bcfff3\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e7acea1 elementor-widget elementor-widget-text-editor\" data-id=\"e7acea1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>University Hospital Essen &#8211; Prof. Dr. Petra Ketteler<\/strong><br \/>The first part of this study characterizes the genetic and genomic features of retinoblastoma subtypes in order to identify biomarkers for tumors with high or low metastatic risk.<br \/>\nIn the second part, the amount of circulating tumor DNA (ctDNA) in biological fluids of retinoblastoma patients will be quantified.<br \/>\nThis is based on the hypothesis that the amount of ctDNA correlates with tumor burden and metastatic risk.<br \/>\nFor this purpose, tumor tissue, blood, cerebrospinal fluid and aqueous humor from 35 patients in 6 centers will be collected to analyze the ctDNA and correlate the results with the clinical course.<br \/>\nThe biomarkers are intended to help identify patients at risk of metastasis in order to reduce the late effects of treatment in others.<br \/>\nCo-BioRB will form the basis for a pan-European study (&#8220;EURBG2&#8221;) on biomarkers for risk stratification in the adjuvant treatment of retinoblastoma.     <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2a5b643 elementor-invisible elementor-widget elementor-widget-image\" data-id=\"2a5b643\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"302\" src=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/06\/KAKS-Publikationen-04.jpg\" class=\"attachment-large size-large wp-image-8757\" alt=\"\" srcset=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/06\/KAKS-Publikationen-04.jpg 950w, https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/06\/KAKS-Publikationen-04-300x113.jpg 300w, https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/06\/KAKS-Publikationen-04-768x290.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-32adfa5 elementor-widget elementor-widget-text-editor\" data-id=\"32adfa5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em>Migration of WERI-RB-1 cells in the first 5 days after injection of<\/em><br \/><em>80-100 suspension cells into the vitreous cavity of the left eye of a<\/em><br \/><em>2-day-old zebrafish<br \/>\n(A) on day of injection,<br \/>\n(B) on day 1,<br \/>\n(C) on day 2 and<br \/>\n(D) on Day 5 post injection in a lateral view;<br \/>\n(E) on the day of Injection with transmitted light<br \/>\n(F) on day 1,<br \/>\n(G) on day 2 and<br \/>\n(H) on day 5 post injection in dorsal view.<br \/>\nOnly the dorsal view shows the initiation of migration of WERI-RB-1 cells in the brain already after one day post injection.<br \/>\nAfter 5 days post injection, only a few cells are found in the eye and most have migrated ti the brain.<br \/>\nOn day 8 post injection no tumor cells were visible (not shown).           <\/em><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-1346\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"7\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-1346\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Use of CAR-T cells in retinoblastoma <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><i aria-hidden=\"true\" class=\"hm hm-minus-large\"><\/i><\/span>\n\t\t\t<span class='e-closed'><i aria-hidden=\"true\" class=\"hm hm-plus-open\"><\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1346\" class=\"elementor-element elementor-element-37b7d06 e-con-full e-flex e-con e-child\" data-id=\"37b7d06\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1346\" class=\"elementor-element elementor-element-739e198 e-con-full e-flex e-con e-child\" data-id=\"739e198\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b8bc04c elementor-widget elementor-widget-text-editor\" data-id=\"b8bc04c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Dr. med Annette K\u00fcnkele &#8211; Charit\u00e9, Universit\u00e4tsmedizin Berlin, Prof. Dr. Ulrich Schraermeyer &#8211; University Hospital T\u00fcbingen<\/strong><br \/><em>Publication of the results of this project to date: Andersch et al.<br \/>\nBMC Cancer (2019) 19:895<a href=\"https:\/\/doi.org\/10.1186\/s12885-019-6131-1\" target=\"_blank\" rel=\"noopener\">(https:\/\/doi.org\/10.1186\/s12885-019-6131-1)<\/a>. <\/em><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1ba1862 elementor-widget elementor-widget-text-editor\" data-id=\"1ba1862\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>In 2016, KAKS initiated the first retinoblastim project using immune cells to combat tumors.<br \/>\nThe aim is for tumor cells to be recognized by certain markers on their surface and destroyed by the body&#8217;s own immune cells.<br \/>\nThe investigations showed that the contact of the immune cells (CAR-T cells) with the cancer cells led to the generation of functional CAR-T cells that were able to specifically recognize these cancer cells by the surface markers, i.e. CD171-specific as well as GD2-specific CAR-T cells.<br \/>\nThe targeted attack of the CAR-T cell via the CD171 or GD2 molecules on the surface of the cancer cells led to the effective killing of all retinoblastoma cells.   <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5665dac elementor-widget elementor-widget-text-editor\" data-id=\"5665dac\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tThe genetically programmed immune cells (CAR-T cells) were so successful in destroying the tumor cells that the next step was to start an in vivo study in T\u00fcbingen.\nFor this purpose, the CAR-T cells from Berlin are being used in a mouse model at the University Hospital in T\u00fcbingen.\nThe mouse model originates from the &#8220;Prevention of radiotherapy induced secondary tumors in retinoblastoma animal models&#8221; project initiated by KAKS several years ago (see below).\nKAKS has brought the two groups together so that the research can now be continued seamlessly and cost-effectively.\nInitiated and funded by KAKS and the company\nCooperVision.     \t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-1347\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"8\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-1347\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Gene analysis of retinal organoids <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><i aria-hidden=\"true\" class=\"hm hm-minus-large\"><\/i><\/span>\n\t\t\t<span class='e-closed'><i aria-hidden=\"true\" class=\"hm hm-plus-open\"><\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1347\" class=\"elementor-element elementor-element-579a033 e-con-full e-flex e-con e-child\" data-id=\"579a033\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1347\" class=\"elementor-element elementor-element-70e3d5d e-con-full e-flex e-con e-child\" data-id=\"70e3d5d\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ac8f291 elementor-widget elementor-widget-text-editor\" data-id=\"ac8f291\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>University Hospital Essen &#8211; Dr. rer.<br \/>\nnat.<br \/>\nDeniz Kanber,  <\/strong><br \/><strong>Prof. Dr. Laura Steenpa\u00df<\/strong><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7f5d2f4 elementor-widget elementor-widget-text-editor\" data-id=\"7f5d2f4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em>Publications: Schipper L, Kanber D, Steenpass L (2018) Generation of heterozygous and homozygous hESC H9 sublines carrying inactivating mutations in RB1.<br \/>\nStem Cell Res. <\/em><br \/><a href=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/06\/Schipper_et_al_Generation_hESC_H9_sublines.pdf\" target=\"_blank\" rel=\"noopener\"><em>PDF for download<\/em><\/a><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fb44b25 elementor-widget elementor-widget-text-editor\" data-id=\"fb44b25\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Why does retinoblastoma develop in the eye and in young children in particular?<br \/>\nIt is not yet clear why the tumor only develops in the eye in young children and which molecular mechanisms contribute to tumor development.<br \/>\nWhat is clear is that the alleles of the retinoblastoma gene are defective (mutated) or missing in all cells in hereditary retinoblastoma and that each cancer develops from a single initial cell.<br \/>\nBut what prevents the development in other cells?<br \/>\nThese cells also no longer have a functioning RB protein (tumor guard), which prevents uncontrolled cell growth in healthy cells.    <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-55fa87c elementor-widget elementor-widget-text-editor\" data-id=\"55fa87c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>However, research on human retinal cells in their developmental stages is not possible.<br \/>\nTherefore, in order to clarify these and other fundamental questions and to find out more about the initial cells of the tumor in the eye, a laboratory model of eye development with stem cells was developed in which the effects of mutations in the retinoblastoma gene can be investigated.<br \/>\nPreviously published results from other groups show that the origin of the tumor appears to be localized in cells of the neural retina and not in the retinal pigment epithelium.  <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6fbd02e elementor-widget elementor-widget-text-editor\" data-id=\"6fbd02e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Specifically, a retinal cell model for retinoblastoma has so far been developed with the help of organoid technology.<br \/>\nThe model is based on human embryonic stem cells (hESC) being made to differentiate as organoids in the laboratory.<br \/>\nOrganoids are organ-like structures that are a few millimetres in size and consist of several cell types of the actual organ.<br \/>\nThe retinal organoids generated in the project exhibit all seven retinal cell types that develop in their natural order in the embryo (ganglion cells, horizontal cells, amacrine cells, cones, rods, bipolar cells and M\u00fcller cells) and are organized in the known retinal layers, i.e. the anglial cell layer, the inner nuclear layer and the outer nuclear layer.   <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cdfba12 elementor-widget elementor-widget-text-editor\" data-id=\"cdfba12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>After successful production of the organoid structures, stem cells were generated that carry a mutation on one or both copies of the retinoblastoma RB1 gene.<br \/>\nThe development of the mutated and non-mutated cells was then compared.<br \/>\nEven with simple means, it was possible to see that the retinal organoids and the retinoblastoma organoids form different structures.<br \/>\nSo far, the observation has only been based on staining of frozen sections and a few targeted RNA analyses.<br \/>\nFor the characterization and for a better understanding of the retinal organoid differentiation with regard to the specific effect of the retinoblastoma mutation (RB1 inactivation), a comprehensive genetic analysis (whole transcriptome analysis) was required in the next step.<br \/>\nThe Children&#8217;s Eye Cancer Foundation funded this analysis.<br \/>\nThe resulting data will provide a fundamental insight into the development and composition of different retinoblastoma cell populations in RB1-mutated organoids and also generate guidelines for sampling and analysis for future work      <br \/><em>Supported by the KAKS.<\/em><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-1348\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"9\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-1348\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Tumor marker development - Liquid Biopsy - Early diagnosis \/ EU project <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><i aria-hidden=\"true\" class=\"hm hm-minus-large\"><\/i><\/span>\n\t\t\t<span class='e-closed'><i aria-hidden=\"true\" class=\"hm hm-plus-open\"><\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1348\" class=\"elementor-element elementor-element-a6161df e-con-full e-flex e-con e-child\" data-id=\"a6161df\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1348\" class=\"elementor-element elementor-element-6f5e019 e-con-full e-flex e-con e-child\" data-id=\"6f5e019\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-200177d elementor-widget elementor-widget-text-editor\" data-id=\"200177d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>EU-funded liquid biopsy project<\/strong><br \/>Another major liquid biopsy project in which KAKS is involved is the EU Era-net Transcan Tumor Marker Project, which is funded by the European Union with over EUR 1 million.<br \/>\nKAKS was also able to fulfill its self-imposed task of providing start-up funding for this project by financing part of the preliminary work at the Free University of Amsterdam (VumC) and also incorporating results and material from the above KAKS tumor marker project at the UK-Essen.<br \/>\nProf. Dr. Petra Temming&#8217;s group, which carried out a large part of the early marker research, is also involved in the EU project.<br \/>\nThe EU-funded tumor marker project started in 2018 with universities from four countries as part of a major research collaboration.<br \/>\nWe are proud that, with the help of A Heart for Children, we were able to contribute to the preparatory work for this important project and are now funding the integration of tumor data from the various national tumor centers.    <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-76ea467 elementor-widget elementor-widget-text-editor\" data-id=\"76ea467\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The aim of the project, which is also funded by the BMBF, is also to develop a non-invasive blood test for the early detection of retinoblastoma or secondary tumors via exosomes (cf.<br \/>\non the preliminary work at <a href=\"http:\/\/dx.doi.org\/10.1016\/j.ccell.2015.09.018\" target=\"_blank\" rel=\"noopener\">http:\/\/dx.doi.org\/10.1016\/j.ccell.2015.09.018)<\/a>.<br \/>\nAt the same time, a systematic and comprehensive retinoblastoma database\/biobank is being set up in the Netherlands with KAKS support and patient data from the last 13 years is being processed.<br \/>\nThe project also focuses on disseminating the results to the specialist public and patients via specialist articles, lectures and regularly updated information.<br \/>\nLast year in Amsterdam, researchers from fifteen centers in Europe, North and South America and Japan founded the IRiSC &#8211; International Retinoblastoma and Second Cancer Consortium as part of this project.<br \/>\nBy including all newly diagnosed cases of Rb and extending medical care, it will now be possible to assess the risks of second tumors much more accurately and develop personalized prevention\/screening.<br \/>\nInternational cooperation is extremely important here because research into rare diseases is very difficult due to the small amount of data available.      <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2245f8e elementor-widget elementor-widget-text-editor\" data-id=\"2245f8e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>KAKS is involved in the following two exciting subprojects.<\/strong><br \/><strong>Hereditary retinoblastoma:<\/strong> Nine centers from Europe and the USA with 115 families are involved in the hereditary retinoblastoma subproject<strong>.<\/strong> <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c82fef3 elementor-widget elementor-widget-text-editor\" data-id=\"c82fef3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tMutation analysis: In the mutation analysis project, it had already become clear in advance that the specific type of mutation is relevant when assessing tumor risks.\nFor this purpose, different types of mutation were categorized into groups and the occurrence data was assigned to these groups and the tumour probability was also determined depending on the mutation.   \t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-70c2f33 elementor-widget elementor-widget-text-editor\" data-id=\"70c2f33\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Another project in this context is the previously reported NIRBtest project for the detection of Rb primary and secondary tumors using a blood test, as originally initiated by KAKS in 2012 with the help of Bild e.V..<br \/>\nThe blood test, for which samples were collected in the first phase, is now based on three blood components: Free tumor DNA, extracellular vesicles and platelets.<br \/>\nAll of these blood elements can provide information about a tumor and are collected centrally, but analyzed in France, the Netherlands or Germany, depending on the type.  <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6fdeeda elementor-widget elementor-widget-text-editor\" data-id=\"6fdeeda\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.cell.com\/cancer-cell\/fulltext\/S1535-6108(15)00349-9\" target=\"_blank\" rel=\"noopener\">https:\/\/www.cell.com\/cancer-cell\/fulltext\/S1535-6108(15)00349-9<\/a><br \/><a href=\"https:\/\/www.gesundheitsforschung-bmbf.de\/de\/nirbtest-8466.php\" target=\"_blank\" rel=\"noopener\">https:\/\/www.gesundheitsforschung-bmbf.de\/de\/nirbtest-8466.php<\/a><br \/><a href=\"https:\/\/www.gesundheitsforschung-bmbf.de\/de\/era-net-transcan-3413.php\" target=\"_blank\" rel=\"noopener\">https:\/\/www.gesundheitsforschung-bmbf.de\/de\/era-net-transcan-3413.php<\/a><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-1349\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"10\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-1349\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Diagnostic path recognition <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><i aria-hidden=\"true\" class=\"hm hm-minus-large\"><\/i><\/span>\n\t\t\t<span class='e-closed'><i aria-hidden=\"true\" class=\"hm hm-plus-open\"><\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1349\" class=\"elementor-element elementor-element-e34d1ba e-con-full e-flex e-con e-child\" data-id=\"e34d1ba\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-1349\" class=\"elementor-element elementor-element-7e39ebb e-con-full e-flex e-con e-child\" data-id=\"7e39ebb\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4f945da elementor-widget elementor-widget-text-editor\" data-id=\"4f945da\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>University Hospital Essen<\/strong><br \/>This study has been completed.<br \/>\nThe aim of this study was to analyze the diagnostic pathway in children with retinoblastoma in order to improve early detection.<br \/>\nThe results show that the most common initial symptoms are leukocoria and strabismus.<br \/>\nThe initial symptoms are mostly noticed by the parents.<br \/>\nHowever, pediatricians often do not attribute these symptoms to a tumor disease.<br \/>\nAnd in the first few months, children usually only see the pediatrician, but not an ophthalmologist.<br \/>\nWe have launched extensive projects to educate paediatricians so that they can recognize retinoblastoma in the future.      <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7726ce8 elementor-widget elementor-widget-text-editor\" data-id=\"7726ce8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Study details: Data was collected from 1049 Rb patients between 1992-2011 in Essen.<br \/>\nThe most common symptoms were leukocoria and strabismus (squint) and it is the parents who usually recognize these symptoms first.<br \/>\nThe survey shows that the time to diagnosis has not changed significantly over the last 20 years.<br \/>\nOur aim is to change this too.<br \/>\nWe already have initial indications that our work is shortening the time to diagnosis.    <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4c708ee elementor-widget elementor-widget-text-editor\" data-id=\"4c708ee\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Status: Completed<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-42385af elementor-widget elementor-widget-text-editor\" data-id=\"42385af\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/06\/WilmDGKJ2013pdf.pdf\" target=\"_blank\" rel=\"noopener\"><em>Analysis of the diagnostic pathway in children with retinoblastoma to improve early detection<\/em><\/a><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-949bd53 elementor-widget elementor-widget-text-editor\" data-id=\"949bd53\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Initiated and supported by KAKS<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-13410\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"11\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-13410\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Rb inhibitors against tumor cells <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><i aria-hidden=\"true\" class=\"hm hm-minus-large\"><\/i><\/span>\n\t\t\t<span class='e-closed'><i aria-hidden=\"true\" class=\"hm hm-plus-open\"><\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-13410\" class=\"elementor-element elementor-element-91029f6 e-con-full e-flex e-con e-child\" data-id=\"91029f6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-13410\" class=\"elementor-element elementor-element-3a77b14 e-con-full e-flex e-con e-child\" data-id=\"3a77b14\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1f8e3b6 elementor-widget elementor-widget-text-editor\" data-id=\"1f8e3b6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>University Hospital Essen &#8211; Dr. Temming<br \/><\/strong>KAKS prefers to fund projects in which substances already known for the treatment of other diseases are used.<br \/>\nSuch substances are generally of no interest for commercial research.<br \/>\nHowever, they have long been tested for their side effects and are usually available on the market at low cost.<br \/>\nOne such project is the KAKS-funded search for potential inhibitors that can be used to treat retinoblastoma.<br \/>\nThe search was successful because the inhibitors against the cell cycle regulator polo-like kinase 1 (PLK1) and against MYCN regulating factors, such as Aurora A kinase and the BET domain protein BRD4, proved to be extremely effective.<br \/>\nThe use of the inhibitors led to a reduction in growth and an increase in cell death (apoptosis) of the retinoblastoma cells in vitro.<br \/>\nThis KAKS-funded study now forms the basis for in vivo studies, which should make a major contribution to the development of new therapies for retinoblastoma patients.      <br \/><em>Supported by the KAKS.<\/em><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-13411\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"12\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-13411\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Late effects study at Essen University Hospital <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><i aria-hidden=\"true\" class=\"hm hm-minus-large\"><\/i><\/span>\n\t\t\t<span class='e-closed'><i aria-hidden=\"true\" class=\"hm hm-plus-open\"><\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-13411\" class=\"elementor-element elementor-element-6ac3c99 e-con-full e-flex e-con e-child\" data-id=\"6ac3c99\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-13411\" class=\"elementor-element elementor-element-e7e3f50 e-con-full e-flex e-con e-child\" data-id=\"e7e3f50\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9904ee2 elementor-widget elementor-widget-text-editor\" data-id=\"9904ee2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Prof. Bornfeld, Prof. Lohmann<\/strong><br \/>KAKS is involved in funding this DKS study<br \/>The aim is to optimize long-term care and improve the long-term prognosis and quality of life.<br \/>\nTo this end, the long-term therapeutic consequences of the various forms of treatment were determined and the individual genetic disposition was also taken into account with regard to the risk of secondary tumors.<br \/>\nIn addition, adult patients and parents were informed about preventive measures.<br \/>\nChildren and adolescents were included in the first phase and adult patients in the second phase (collective of approx. 570 test subjects).   <\/p>\n<p>Status: The studies have been completed and the results are available.<br \/>\nThe results of the first phases have since been published (Temming et al. 2015, Pediatric Blood Cancer) <br \/><em>Sponsored by KAKS and the German Childhood Cancer Foundation.<\/em><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-13412\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"13\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-13412\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Prevention of radiotherapy induced secondary tumors <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><i aria-hidden=\"true\" class=\"hm hm-minus-large\"><\/i><\/span>\n\t\t\t<span class='e-closed'><i aria-hidden=\"true\" class=\"hm hm-plus-open\"><\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-13412\" class=\"elementor-element elementor-element-b7715f9 e-con-full e-flex e-con e-child\" data-id=\"b7715f9\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-13412\" class=\"elementor-element elementor-element-84dbfa0 e-con-full e-flex e-con e-child\" data-id=\"84dbfa0\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-475016e elementor-widget elementor-widget-text-editor\" data-id=\"475016e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Dr. Sylvie Julien, Prof. Dr. Ulrich Schraermeyer, Prof. Dr. H. Peter Rodemann &#8211; University Hospital T\u00fcbingen<\/strong><br \/><strong>Status: Completed<\/strong><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bfded37 elementor-widget elementor-widget-text-editor\" data-id=\"bfded37\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Published under <em><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27694105\" target=\"_blank\" rel=\"noopener\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27694105<\/a><\/em><br \/><em>Initiated by KAKS and supported by the German Childhood Cancer Foundation.<\/em><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c5373bf elementor-widget elementor-widget-text-editor\" data-id=\"c5373bf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Abstract<\/strong><br \/>Retinoblastoma (Rb) is the most frequent primary intraocular tumor in children and, if left untreated, can cause death.<br \/>\nPreclinical animal models that mimic molecular, genetic, and cellular features of cancers are essential for studying cancer and searching for promising diagnosis and treatment modalities.<br \/>\nThere are several models described for Rb, but none of them fully meet our requirements.<br \/>\nThe aim of this study was to create a novel xenograft-nude mouse-model with broad application possibilities, which closely resembles the clinical observations of Rb patients and which could be used to investigate the development and spread of the tumour by using scanning laser ophthalmoscopy\/optical coherence tomography (SLO\/OCT) as well as histology methods.<br \/>\nWe injected human retinoblastoma Y79 cells intravitreally into both eyes of immune-deficient nude mice.<br \/>\nThe incidences of retinoblastoma as well as growth velocity were analyzed 3, 6, 9 and 12 weeks after cell injection in vivo by SLO\/OCT as well as ex vivo by electron microscopy (EM) and hematoxylin\/eosin (HE) staining.<br \/>\nFurthermore, internal organs were histologically screened for potentially occurring metastases.<br \/>\nThree weeks post-injection, animals developed a retinoblastoma, and after five weeks tumor growth resulted in swelling of the eyes in individual animals, showing a similar phenotype to that of untreated Rb patients at advanced stages of tumor-development.<br \/>\nAfter 12 weeks, 67.5% of all analyzed eyes (29 of 42) contained a retinoblastoma.<br \/>\nAt early stages of Rb development, the SLO\/OCT analysis correlated with the histology results.<br \/>\nIf the tumors were too large, only histological investigations were feasible.<br \/>\nThe ultrastructural characteristics of the xenograft tumors were very similar to those described for patient&#8217;s tumors.<br \/>\nIn one mouse, brain metastases were observed.<br \/>\nOur retinoblastoma mouse model closely resembles the human disease.<br \/>\nSLO\/OCT can be used for the detection of Rb at early stages of development and could be used for monitoring the success of future therapies.              <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-13413\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"14\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-13413\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Tumor marker development <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><i aria-hidden=\"true\" class=\"hm hm-minus-large\"><\/i><\/span>\n\t\t\t<span class='e-closed'><i aria-hidden=\"true\" class=\"hm hm-plus-open\"><\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-13413\" class=\"elementor-element elementor-element-38e4d37 e-con-full e-flex e-con e-child\" data-id=\"38e4d37\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-13413\" class=\"elementor-element elementor-element-67e7c34 e-con-full e-flex e-con e-child\" data-id=\"67e7c34\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-531ebe1 elementor-widget elementor-widget-text-editor\" data-id=\"531ebe1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Liquid Biospy &#8211; Early diagnosis<\/strong><br \/><strong>Charit\u00e9 Berlin and University Hospital Essen<\/strong><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dc9087d elementor-widget elementor-widget-text-editor\" data-id=\"dc9087d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Research into the early detection of cancer through blood analysis (&#8220;liquid biopsy&#8221;) has made enormous progress in recent years: experts speak of a &#8220;revolution&#8221; and &#8220;breakthrough&#8221; in the early detection of cancer.<br \/>\nKAKS is right in the middle of this with two tumor marker projects (Berlin and Amsterdam). <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-59fcc1a elementor-widget elementor-widget-text-editor\" data-id=\"59fcc1a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Blood analysis was tackled as a central research objective by the KAKS at a very early stage.<br \/>\nThree approaches were initially tried for the early detection of retinoblastomas and secondary tumors in blood samples:<br \/>\n1. early detection of antibodies in the blood that the body had previously produced against cancer cells<br \/>\n2. identification of cancer cell surface markers,<br \/>\n3. detection of tumor cells circulating in the blood.<br \/>\nThese approaches were researched with the support of Bild e.V. Ein Herz f\u00fcr Kinder and the KAKS at the Max Planck Institute in Potsdam in the team of Peter Seeberger and the UK-Essen in the team of Petra Temming.<br \/>\nWe were able to identify useful cancer marker proteins on the cell surface of cancer cells in the test tube.<br \/>\nHowever, these approaches then showed that the antibodies and the circulating tumor cells do not have the necessary sensitivity for detection in the patient&#8217;s blood.       <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e1a2c67 elementor-widget elementor-widget-text-editor\" data-id=\"e1a2c67\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The project at the Charit\u00e9 in Berlin was then expanded to include the latest highly sensitive &#8220;liquid biopsy&#8221; technologies for the analysis of tumor DNA in blood and also a marker protein analysis by one of the most successful marker specialists, Dr. Bergmann.<br \/>\nAgain with the support of Bild e.V., we financed a doctoral thesis to establish a standardized protocol for the processing of blood samples, which should ensure that samples obtained can be properly processed independently of the user and in such a way that even small amounts of tumor DNA can be identified in the sample. <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6036f83 elementor-widget elementor-widget-text-editor\" data-id=\"6036f83\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Furthermore, a list of candidate genes and genomic alterations that are typical of the most common secondary tumors was compiled by means of literature research and the re-analysis of publicly available sequencing data.<br \/>\nThis list, together with precise information on which DNA regions need to be covered in which way when sequencing the patient&#8217;s blood, forms the basis for the sequencing-based early detection test. <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4925122 elementor-widget elementor-widget-text-editor\" data-id=\"4925122\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>In addition to the retinoblastoma gene RB1, this test also takes into account those genes that are most frequently altered in secondary tumors.<br \/>\nAfter processing the blood, special probes are now used to detect the DNA sections of the cancer cells and the candidate genes are specifically examined for characteristic changes using a so-called hybrid capture sequencing assay. <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-537d00e elementor-widget elementor-widget-text-editor\" data-id=\"537d00e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>In parallel approaches, the DNA tests are tested on the blood of retinoblastoma patients and various second tumor types as well as on healthy people for comparison.<br \/>\nMost recently, a comparable technique was able to detect 8 different tumors in the blood of 98% of patients. <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-828d8f1 elementor-widget elementor-widget-text-editor\" data-id=\"828d8f1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em>Initiated by KAKS, sponsored by KAKS and Bild hilft e.V. &#8211; Ein Herz f\u00fcr Kinder<\/em><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0c8b60a e-flex e-con-boxed e-con e-parent\" data-id=\"0c8b60a\" data-element_type=\"container\" data-e-type=\"container\" id=\"projektfoerderung\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-24e318c e-con-full e-flex e-con e-child\" data-id=\"24e318c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-701098b elementor-widget elementor-widget-spacer\" data-id=\"701098b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-257222e elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"257222e\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">PROJECT- <br> PROMOTION<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-79ad525 e-con-full e-flex e-con e-child\" data-id=\"79ad525\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-51968c1 elementor-widget elementor-widget-spacer\" data-id=\"51968c1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ac99190 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"ac99190\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>The Children&#8217;s Eye Cancer Foundation primarily supports therapy optimization studies and application-oriented scientific projects.<\/strong><\/p>\n<p>As a trust foundation of the German Childhood Cancer Foundation (DKS), we, the Children&#8217;s Eye Cancer Foundation, are in the fortunate position of being able to draw on the resources of this large foundation.<br \/>\nIn order to meet high quality standards, the German Childhood Cancer Foundation has appointed a panel of experts: Seven experts advise the foundation and the Children&#8217;s Eye Cancer Foundation on all matters relating to project funding. <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-185223a elementor-widget elementor-widget-spacer\" data-id=\"185223a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-89ab84b elementor-invisible elementor-widget elementor-widget-image\" data-id=\"89ab84b\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"459\" src=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/03\/KAKS-Projektfoerderung-01-1024x588.jpg\" class=\"attachment-large size-large wp-image-4995\" alt=\"\" srcset=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/03\/KAKS-Projektfoerderung-01-1024x588.jpg 1024w, https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/03\/KAKS-Projektfoerderung-01-300x172.jpg 300w, https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/03\/KAKS-Projektfoerderung-01-768x441.jpg 768w, https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/03\/KAKS-Projektfoerderung-01-1536x883.jpg 1536w, https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/03\/KAKS-Projektfoerderung-01.jpg 1890w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c08f1b1 elementor-widget elementor-widget-spacer\" data-id=\"c08f1b1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9804dfb elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"9804dfb\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Invitation to tender<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-939bca0 elementor-widget elementor-widget-spacer\" data-id=\"939bca0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-60f9f55 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"60f9f55\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Project applications undergo a standardized review process.<br \/>\nFor larger research projects, we are able to draw on the DKS&#8217;s highly developed review process, including a panel of experts, thanks to its generous support.<br \/>\nThe expert committee has received a mandate from the German Childhood Cancer Foundation to evaluate all project applications and make decisions in agreement with the Foundation&#8217;s Board of Directors.  <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cb62bb2 elementor-widget elementor-widget-spacer\" data-id=\"cb62bb2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-feb4ee1 elementor-widget elementor-widget-spacer\" data-id=\"feb4ee1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-31be1ff elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"31be1ff\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Composition of the expert committee of the German Childhood Cancer Foundation<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dec839a elementor-widget elementor-widget-spacer\" data-id=\"dec839a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-65ddab6 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"65ddab6\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Prof. Dr. Dr. med. Michael Fr\u00fchwald, Augsburg (Chair)<br \/>PD Dr. med. Gabriele Escherich, Hamburg (Deputy Chair)<br \/>Prof. Dr. med. Uta Dirksen, Essen<br \/>PD Dr. med. univ.<br \/>\nPhD Miriam Erlacher, Freiburg<br \/>Prof. Dr. med. Jan-Henning Klusmann, Frankfurt<br \/>Prof. Dr. med. Stefan Pfister, Heidelberg<br \/>Prof. Dr. med. Martin Stanulla, Hanover <\/p>\n<p>The expert committee meets twice a year in a closed meeting.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6b90395 elementor-widget elementor-widget-spacer\" data-id=\"6b90395\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-679e6a4 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"679e6a4\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Information on the procedure<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bf9cb85 elementor-widget elementor-widget-spacer\" data-id=\"bf9cb85\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-db6e42c elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"db6e42c\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The planned research project must be in the field of all diseases and secondary diseases associated with retinoblastoma and meet the funding criteria of the Children&#8217;s Eye Cancer Foundation.<br \/>\nProject applications can be submitted at any time.<br \/>\n(Source: German Childhood Cancer Foundation).  <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2f7d0ef e-con-full e-flex e-con e-child\" data-id=\"2f7d0ef\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3b2ee65 elementor-align-right elementor-invisible elementor-widget elementor-widget-button\" data-id=\"3b2ee65\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/05\/Antragsrichtlinien-KAKS-13.pdf\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Application guidelines<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4689a2a elementor-align-right elementor-invisible elementor-widget elementor-widget-button\" data-id=\"4689a2a\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/05\/KAKS_20121012i_Formular_Antrag_Forschung_.pdf\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Application form<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2ca6225b e-flex e-con-boxed e-con e-parent\" data-id=\"2ca6225b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-19f55c08 e-con-full e-flex e-con e-child\" data-id=\"19f55c08\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ed23911 elementor-invisible elementor-widget elementor-widget-image\" data-id=\"ed23911\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInLeft&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"533\" src=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/03\/KAKS-Gutes-tun-spenden.jpg\" class=\"attachment-large size-large wp-image-5003\" alt=\"\" srcset=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/03\/KAKS-Gutes-tun-spenden.jpg 900w, https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/03\/KAKS-Gutes-tun-spenden-300x200.jpg 300w, https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/03\/KAKS-Gutes-tun-spenden-768x512.jpg 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7c159803 e-con-full e-flex e-con e-child\" data-id=\"7c159803\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6ed65858 elementor-absolute elementor-view-default elementor-invisible elementor-widget elementor-widget-icon\" data-id=\"6ed65858\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;,&quot;_animation&quot;:&quot;fadeInRight&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" height=\"140\" viewBox=\"0 0 151.192 140\" width=\"151.192\"><clipPath id=\"a\"><path d=\"m0 0h151.192v140h-151.192z\"><\/path><\/clipPath><clipPath id=\"b\"><path d=\"m0 0h74.797v68.922h-74.797z\"><\/path><\/clipPath><g clip-path=\"url(#a)\"><path d=\"m128.457 110.044c-15.867 20.913-34.295 29.956-58.457 29.956a70 70 0 1 1 19.972-137.108s13.771 3.784 22.984 15.292c0 0 7.659 8.213 13.346 10.219a26.335 26.335 0 0 0 8.53 1.418 26.267 26.267 0 0 0 16.348-5.674s1.27 54.276-22.723 85.9\" fill=\"#f80000\"><\/path><\/g><g clip-path=\"url(#b)\" transform=\"translate(33.441 36.34)\"><path d=\"m35.116 66.029.382.116c1.4.425 2.731.826 3.606 2.583a.345.345 0 0 0 .091.115.337.337 0 0 0 .221.079.345.345 0 0 0 .191-.057c.645-.424 1.252-.808 1.829-1.173 1.208-.764 2.251-1.424 3.249-2.193a59.577 59.577 0 0 0 9.735-9.229c3.8-4.594 7.727-9.344 11.426-14.316a85.76 85.76 0 0 0 5.955-9.6 24.222 24.222 0 0 0 2.911-9.9 22.825 22.825 0 0 0 -4-15.288c-3.45-4.936-8.043-7.341-13.639-7.156a23.986 23.986 0 0 0 -16.5 7.242 6.894 6.894 0 0 0 -.624.748 2.844 2.844 0 0 1 -1.217 1.1c-5.41-5.318-9.545-7.4-15.732-7.933-6.349-.547-11.489 1.514-15.277 6.125a44.2 44.2 0 0 0 -4.923 7.357 23.183 23.183 0 0 0 -1.83 17.719 44.3 44.3 0 0 0 7.659 15.118 52.978 52.978 0 0 0 26.487 18.543m-26.189-50.319a43.188 43.188 0 0 1 2.71-4.475 11.346 11.346 0 0 1 9.903-5.235q.784 0 1.609.081a18.327 18.327 0 0 1 13.431 7.45c.394.527.823 1.015 1.2 1.445.154.175.3.34.427.492a.349.349 0 0 0 .207.118 2.241 2.241 0 0 0 2.592-1.3c2.633-4.41 6.732-7.043 12.9-8.284a15.066 15.066 0 0 1 4.421-.111 8.44 8.44 0 0 1 5.958 3.444 15.028 15.028 0 0 1 3.132 8.242 19.059 19.059 0 0 1 -1.824 10.1 60.941 60.941 0 0 1 -3.9 7.027c-2.7 4.012-5.577 8-8.361 11.857l-.968 1.342c-2.073 2.875-4.218 5.773-6.291 8.576q-1.122 1.521-2.243 3.037c-.323.437-.658.865-1.013 1.318l-.357.457-2.913-1.211c-2.242-.931-4.379-1.819-6.511-2.72a47.043 47.043 0 0 1 -15.712-10.7 41.424 41.424 0 0 1 -9.7-15.554 18.835 18.835 0 0 1 1.3-15.4\" fill=\"#fff\"><\/path><\/g><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6bf3af22 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"6bf3af22\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Doing good, donating or endowing<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6ef0b7b2 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"6ef0b7b2\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Thank you for your support.<br \/>\nWhether research, early detection or parent-child projects &#8211; at KAKS, distances are short and your donation goes directly to the right place. <\/strong><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ec4f7bc elementor-widget elementor-widget-spacer\" data-id=\"ec4f7bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7edbb18 e-con-full e-flex e-con e-child\" data-id=\"7edbb18\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-92f2a33 elementor-align-left elementor-invisible elementor-widget elementor-widget-button\" data-id=\"92f2a33\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/kinderaugenkrebsstiftung.de\/en\/donations\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Donate now<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-640ef3f e-flex e-con-boxed e-con e-parent\" data-id=\"640ef3f\" data-element_type=\"container\" data-e-type=\"container\" id=\"forschungspartner\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-ecadfb1 e-con-full e-flex e-con e-child\" data-id=\"ecadfb1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3e18736 elementor-widget elementor-widget-spacer\" data-id=\"3e18736\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b749fec elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"b749fec\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Research <br> partner<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8003de1 e-con-full e-flex e-con e-child\" data-id=\"8003de1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c074e1f elementor-widget elementor-widget-spacer\" data-id=\"c074e1f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-722e9da elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"722e9da\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">A heartfelt thank you<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5e537fd elementor-widget elementor-widget-spacer\" data-id=\"5e537fd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8373c15 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"8373c15\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul>\n<li>University Hospital T\u00fcbingen, Clinic for Ophthalmology<\/li>\n<li>Max Planck Institute of Colloids and Interfaces, Potsdam<\/li>\n<li>University Hospital Essen, Clinic for Ophthalmology<\/li>\n<li>University Hospital Children&#8217;s Hospital III Essen<\/li>\n<li>Essen University Hospital, Institute of Human Genetics<\/li>\n<li>University Hospital Amsterdam, Holland<\/li>\n<li>Charite, Children&#8217;s Hospital<\/li>\n<li>University Hospital M\u00fcnster<\/li>\n<li>University Medical Center Schleswig-Holstein<\/li>\n<\/ul>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-46597da7 e-flex e-con-boxed e-con e-parent\" data-id=\"46597da7\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:&quot;yes&quot;,&quot;_ha_eqh_widget&quot;:[&quot;ha-infobox&quot;],&quot;_ha_eqh_disable_on_tablet&quot;:&quot;yes&quot;,&quot;_ha_eqh_to&quot;:&quot;widget&quot;,&quot;_ha_eqh_disable_on_mobile&quot;:&quot;yes&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-392cf3ab elementor-widget elementor-widget-heading\" data-id=\"392cf3ab\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Further information<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-58f4f46a e-con-full e-flex e-con e-child\" data-id=\"58f4f46a\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t<div class=\"elementor-element elementor-element-1ec45efe e-con-full e-flex e-con e-child\" data-id=\"1ec45efe\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-625ce6d ha-infobox-media-dir-top ha-has-bg-overlay elementor-invisible elementor-widget elementor-widget-ha-infobox happy-addon ha-infobox\" data-id=\"625ce6d\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"ha-infobox.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n\t\t\n\t\t<div class=\"ha-infobox-body\">\n\t\t\t<h3 class=\"ha-infobox-title\"><br>Donations<\/h3>\n\t\t\t\n\t\t\t<a class=\"ha-btn ha-btn--link\" href=\"https:\/\/kinderaugenkrebsstiftung.de\/en\/donations\/\"><span class=\"ha-btn-text\">Learn more<\/span><\/a>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-faf639 e-con-full e-flex e-con e-child\" data-id=\"faf639\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-48602e5f ha-infobox-media-dir-top ha-has-bg-overlay elementor-invisible elementor-widget elementor-widget-ha-infobox happy-addon ha-infobox\" data-id=\"48602e5f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"ha-infobox.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n\t\t\n\t\t<div class=\"ha-infobox-body\">\n\t\t\t<h3 class=\"ha-infobox-title\">International projects<\/h3>\n\t\t\t\n\t\t\t<a class=\"ha-btn ha-btn--link\" href=\"https:\/\/kinderaugenkrebsstiftung.de\/en\/about-us\/what-we-do\/international-projects\/\"><span class=\"ha-btn-text\">Learn more<\/span><\/a>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-16880a6b e-con-full e-flex e-con e-child\" data-id=\"16880a6b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1142732d ha-infobox-media-dir-top ha-has-bg-overlay elementor-invisible elementor-widget elementor-widget-ha-infobox happy-addon ha-infobox\" data-id=\"1142732d\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"ha-infobox.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n\t\t\n\t\t<div class=\"ha-infobox-body\">\n\t\t\t<h3 class=\"ha-infobox-title\">News &amp;<br> Insights<\/h3>\n\t\t\t\n\t\t\t<a class=\"ha-btn ha-btn--link\" href=\"https:\/\/kinderaugenkrebsstiftung.de\/en\/news-insights\/\"><span class=\"ha-btn-text\">Learn more<\/span><\/a>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Research Research into the mechanisms and possible therapeutics for retinoblastoma not only benefits retinoblastoma children, but has great potential to serve as a basis for all cancers. &#8220;When the final history of cancer research is one day written, retinoblastoma will deserve its own chapter. Studies of this rare childhood tumor have yielded the first widely [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":12293,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"uix_meta_title":"","uix_meta_description":"","uix_canonical_url":"","footnotes":""},"class_list":["post-12355","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/kinderaugenkrebsstiftung.de\/en\/wp-json\/wp\/v2\/pages\/12355","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kinderaugenkrebsstiftung.de\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/kinderaugenkrebsstiftung.de\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/kinderaugenkrebsstiftung.de\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kinderaugenkrebsstiftung.de\/en\/wp-json\/wp\/v2\/comments?post=12355"}],"version-history":[{"count":0,"href":"https:\/\/kinderaugenkrebsstiftung.de\/en\/wp-json\/wp\/v2\/pages\/12355\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/kinderaugenkrebsstiftung.de\/en\/wp-json\/wp\/v2\/pages\/12293"}],"wp:attachment":[{"href":"https:\/\/kinderaugenkrebsstiftung.de\/en\/wp-json\/wp\/v2\/media?parent=12355"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}