{"id":12480,"date":"2024-01-09T14:56:36","date_gmt":"2024-01-09T13:56:36","guid":{"rendered":"https:\/\/kaks.hb-dev.de\/about-retinoblastoma\/clinical-picture\/"},"modified":"2024-09-25T15:32:34","modified_gmt":"2024-09-25T13:32:34","slug":"clinical-picture","status":"publish","type":"page","link":"https:\/\/kinderaugenkrebsstiftung.de\/en\/about-retinoblastoma\/clinical-picture\/","title":{"rendered":"Clinical picture"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"12480\" class=\"elementor elementor-12480 elementor-290\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6be3c32c e-flex e-con-boxed e-con e-parent\" data-id=\"6be3c32c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-12913bbb elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"12913bbb\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">Definition <br> Clinical picture<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-43882c10 e-flex e-con-boxed e-con e-parent\" data-id=\"43882c10\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-282aa8ee elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"282aa8ee\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Retinoblastoma is a rare cancer of the eye.<br \/>\nIt develops in the retina and occurs almost exclusively in children. <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4168961e e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"4168961e\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;animation&quot;:&quot;fadeIn&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-37d58741 elementor-widget-laptop__width-initial elementor-widget-tablet_extra__width-initial elementor-widget elementor-widget-ha-breadcrumbs happy-addon ha-breadcrumbs happy-addon-pro\" data-id=\"37d58741\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"ha-breadcrumbs.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<ul class=\"ha-breadcrumbs\"><li class=\"ha-breadcrumbs-item ha-breadcrumbs-start\"><a href=\"https:\/\/kinderaugenkrebsstiftung.de\/en\/\" rel=\"home\"><span class=\"ha-breadcrumbs-text\"><span class=\"ha-breadcrumbs-home-icon\"><span class=\"fas fa-home\" aria-hidden=\"true\"><\/span><\/span><\/span><\/a><\/li><\/ul>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-42de157d e-flex e-con-boxed e-con e-parent\" data-id=\"42de157d\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2a0b423f e-con-full e-flex e-con e-child\" data-id=\"2a0b423f\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7b6f5ef2 elementor-invisible elementor-widget elementor-widget-image\" data-id=\"7b6f5ef2\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"457\" src=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/02\/Definition-Krankheitsbild-01-1024x585.jpg\" class=\"attachment-large size-large wp-image-3614\" alt=\"\" srcset=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/02\/Definition-Krankheitsbild-01-1024x585.jpg 1024w, https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/02\/Definition-Krankheitsbild-01-300x171.jpg 300w, https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/02\/Definition-Krankheitsbild-01-768x439.jpg 768w, https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/02\/Definition-Krankheitsbild-01-1536x878.jpg 1536w, https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/02\/Definition-Krankheitsbild-01.jpg 1900w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5a38aff3 elementor-widget elementor-widget-spacer\" data-id=\"5a38aff3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-57573a7f elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"57573a7f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A distinction is made between a hereditary and a non-hereditary form of the disease.<br \/>\nIn the first case, there is a predisposition for the development of this type of cancer, in the second case, the cancer develops spontaneously, i.e. as a result of a newly occurring change in a retinal cell. <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-fa27abf e-flex e-con-boxed e-con e-parent\" data-id=\"fa27abf\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-5d71801 e-con-full e-flex e-con e-child\" data-id=\"5d71801\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2ad9745 elementor-invisible elementor-widget elementor-widget-n-accordion\" data-id=\"2ad9745\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;default_state&quot;:&quot;all_collapsed&quot;,&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;max_items_expended&quot;:&quot;one&quot;,&quot;n_accordion_animation_duration&quot;:{&quot;unit&quot;:&quot;ms&quot;,&quot;size&quot;:400,&quot;sizes&quot;:[]}}\" data-widget_type=\"nested-accordion.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"e-n-accordion\" aria-label=\"Accordion. Open links with Enter or Space, close with Escape, and navigate with Arrow Keys\">\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-4490\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"1\" tabindex=\"0\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-4490\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Definition of <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><i aria-hidden=\"true\" class=\"hm hm-minus-large\"><\/i><\/span>\n\t\t\t<span class='e-closed'><i aria-hidden=\"true\" class=\"hm hm-plus-open\"><\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-4490\" class=\"elementor-element elementor-element-ad8351b e-con-full e-flex e-con e-child\" data-id=\"ad8351b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-4490\" class=\"elementor-element elementor-element-ae46f9e e-con-full e-flex e-con e-child\" data-id=\"ae46f9e\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3c61546 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"3c61546\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>A retinoblastoma can affect one or both eyes.<br \/>\nIn most cases (around 60% of cases), only one eye is affected, which is referred to as unilateral or unilateral retinoblastoma.<br \/>\nIn around 40% of children, the disease affects both eyes (bilateral retinoblastoma).<br \/>\nIf the latter is the case, this is almost always an indication of a hereditary retinoblastoma.<br \/>\nUnilateral retinoblastomas, on the other hand, are usually not hereditary.<br \/>\nThe tumors can either form at only one location in the eye (unifocal) or at several locations (multifocal).     &nbsp;<\/p>\n<p>Retinoblastomas usually grow rapidly.<br \/>\nThey can spread within the eyeball and, starting from there, also into the eye socket and along the optic nerve into the central nervous system (CNS), and in advanced cases also into other organs via the blood and\/or lymphatic system.<br \/>\nIf the disease remains untreated, it is almost always fatal.<br \/>\nOnly in very rare cases (1%) does the tumor regress on its own; this is referred to as spontaneous regression.   &nbsp;<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f783371 elementor-widget elementor-widget-spacer\" data-id=\"f783371\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ec23ead elementor-invisible elementor-widget elementor-widget-video\" data-id=\"ec23ead\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/www.youtube.com\\\/watch?v=SFjxjIWDbqs&quot;,&quot;show_image_overlay&quot;:&quot;yes&quot;,&quot;image_overlay&quot;:{&quot;url&quot;:&quot;https:\\\/\\\/kinderaugenkrebsstiftung.de\\\/wp-content\\\/uploads\\\/2024\\\/02\\\/What-is-retinoblastoma-Video-Preview.jpg&quot;,&quot;id&quot;:3643,&quot;size&quot;:&quot;&quot;,&quot;alt&quot;:&quot;&quot;,&quot;source&quot;:&quot;library&quot;},&quot;lightbox&quot;:&quot;yes&quot;,&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-wrapper\" data-borlabs-cookie-remove-container-on-unlocking> <div class=\"brlbs-cmpnt-container brlbs-cmpnt-content-blocker brlbs-cmpnt-with-individual-styles\" data-borlabs-cookie-content-blocker-id=\"youtube-content-blocker\" 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class=\"brlbs-cmpnt-cb-preset-c brlbs-cmpnt-cb-youtube\"> <div class=\"brlbs-cmpnt-cb-thumbnail\" style=\"background-image: url('https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/02\/What-is-retinoblastoma-Video-Preview.jpg')\"><\/div> <div class=\"brlbs-cmpnt-cb-main\"> <div class=\"brlbs-cmpnt-cb-play-button\"><\/div> <div class=\"brlbs-cmpnt-cb-content\"> <p class=\"brlbs-cmpnt-cb-description\">You are currently viewing a placeholder content from <strong>YouTube<\/strong>. To access the actual content, click the button below. Please note that doing so will share data with third-party providers.<\/p> <a class=\"brlbs-cmpnt-cb-provider-toggle\" href=\"#\" data-borlabs-cookie-show-provider-information role=\"button\">More Information<\/a> <\/div> <div class=\"brlbs-cmpnt-cb-buttons\"> <a class=\"brlbs-cmpnt-cb-btn\" href=\"#\" data-borlabs-cookie-unblock role=\"button\">Unblock content<\/a> <a class=\"brlbs-cmpnt-cb-btn\" href=\"#\" data-borlabs-cookie-accept-service role=\"button\" style=\"display: inherit\">Accept required service and unblock content<\/a> <\/div> <\/div> <\/div><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-4491\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"2\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-4491\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Frequency <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><i aria-hidden=\"true\" class=\"hm hm-minus-large\"><\/i><\/span>\n\t\t\t<span class='e-closed'><i aria-hidden=\"true\" class=\"hm hm-plus-open\"><\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-4491\" class=\"elementor-element elementor-element-68da46b e-flex e-con-boxed e-con e-child\" data-id=\"68da46b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-4491\" class=\"elementor-element elementor-element-9e18722 e-con-full e-flex e-con e-child\" data-id=\"9e18722\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a5a1ea4 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"a5a1ea4\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Retinoblastoma is the most common malignant tumor occurring in the eye (intraocular) in children.<br \/>\nAccording to the German Childhood Cancer Registry (Mainz), around 45 children under the age of 18 are newly diagnosed with this form of cancer in Germany every year. <\/b><\/p>\n<p>Overall, however, retinoblastomas are rare: They account for around 2% of all malignant diseases in children and adolescents.<\/p>\n<p>Retinoblastoma usually occurs in infants and young children, i.e. almost all affected children are under 5 years old, although bilaterally affected children are usually younger than those with unilateral retinoblastoma.<br \/>\nThe average age of onset is 1 year.<br \/>\nBoys are affected slightly more frequently than girls (gender ratio: 1.1:1).  <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-4492\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"3\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-4492\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Causes <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><i aria-hidden=\"true\" class=\"hm hm-minus-large\"><\/i><\/span>\n\t\t\t<span class='e-closed'><i aria-hidden=\"true\" class=\"hm hm-plus-open\"><\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-4492\" class=\"elementor-element elementor-element-e0cacad e-flex e-con-boxed e-con e-child\" data-id=\"e0cacad\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-4492\" class=\"elementor-element elementor-element-68282f8 e-con-full e-flex e-con e-child\" data-id=\"68282f8\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-91540c0 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"91540c0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>The development of retinoblastoma is caused by two genetic changes (mutations) in the precursor cells of the retina.<\/strong>  Such changes can occur spontaneously in individual retinal cells.<br \/>\nHowever, they can also be present in the germ cells (and therefore also in all body cells) and are then hereditary.   <br \/>Just over half of the patients have a non-hereditary form of retinoblastoma, i.e. the mutations have arisen in isolation (sporadically) and are located exclusively in the tumor cells.  <strong>However, almost 50% of retinoblastomas are hereditary.<\/strong>  In around a quarter of these cases &#8211; i.e. in a total of 10 to 15% of all patients &#8211; other diseases are already known in the family (this is also referred to as familial retinoblastoma).  <br \/>Regardless of whether it is a hereditary or non-hereditary retinoblastoma, the genetic changes are always located in the so-called retinoblastoma gene, which is found on chromosome 13.<br \/>\nAs each chromosome is present in duplicate, there are also two retinoblastoma gene alleles in each cell.<br \/>\nA tumor can only develop if both alleles are altered.<br \/>\nHowever, as all retinal cells in hereditary retinoblastoma already have an altered retinoblastoma gene allele from the outset, &#8220;only&#8221; one further mutation is necessary for tumor development.<br \/>\nTherefore, the hereditary form usually occurs at a very early age, in both eyes (bilateral) and often at several sites (multifocal) within one eye.      <strong>For children who have inherited the diseased gene, the risk of developing retinoblastoma is almost 100%.<br \/>\nAs the predisposition to other cancers is also increased, hereditary retinoblastoma is also referred to as cancer predisposition syndrome. <\/strong><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t\t<details id=\"e-n-accordion-item-4493\" class=\"e-n-accordion-item\" >\n\t\t\t\t<summary class=\"e-n-accordion-item-title\" data-accordion-index=\"4\" tabindex=\"-1\" aria-expanded=\"false\" aria-controls=\"e-n-accordion-item-4493\" >\n\t\t\t\t\t<span class='e-n-accordion-item-title-header'><div class=\"e-n-accordion-item-title-text\"> Signs of illness <\/div><\/span>\n\t\t\t\t\t\t\t<span class='e-n-accordion-item-title-icon'>\n\t\t\t<span class='e-opened' ><i aria-hidden=\"true\" class=\"hm hm-minus-large\"><\/i><\/span>\n\t\t\t<span class='e-closed'><i aria-hidden=\"true\" class=\"hm hm-plus-open\"><\/i><\/span>\n\t\t<\/span>\n\n\t\t\t\t\t\t<\/summary>\n\t\t\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-4493\" class=\"elementor-element elementor-element-10c1217 e-flex e-con-boxed e-con e-child\" data-id=\"10c1217\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div role=\"region\" aria-labelledby=\"e-n-accordion-item-4493\" class=\"elementor-element elementor-element-1dd8c6b e-con-full e-flex e-con e-child\" data-id=\"1dd8c6b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-66f850d elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"66f850d\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Very small retinoblastomas usually do not cause any symptoms; the disease often progresses for a long time without any signs of illness (symptoms).<br \/>\nSymptoms usually only occur when the tumor is larger or grows into other parts of the eye.<br \/>\nThis can lead to impaired vision or even blindness.    <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-862dffc elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"862dffc\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>However, the most common initial symptom in over two thirds of children with the disease is a white pupil (leukocoria) that lights up in certain light conditions,<\/strong> for example when taking photographs &#8211; in contrast to a red pupil or a black pupil in a healthy eye.<br \/>\nThis white pupil, also known as a cat&#8217;s eye, can be an indication of tumor growth in the eye.<br \/>\nIn addition, strabismus can occur in the affected eye due to the misalignment of the visual axis.<br \/>\nMore rarely, children are affected by other visual disorders or by a painful, reddened and\/or swollen eye due to increased intraocular pressure.   <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1db7e45 elementor-align-left elementor-invisible elementor-widget elementor-widget-button\" data-id=\"1db7e45\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/kinderaugenkrebsstiftung.de\/en\/about-retinoblastoma\/warning-signs\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">6 Warning signs<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b994736 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"b994736\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>However, the occurrence of one or more of these symptoms does not necessarily mean that a retinoblastoma or other tumor disease is present.<\/strong>  Some of these symptoms can also have comparatively harmless causes that have nothing to do with a tumor.<br \/>\nNevertheless, it is advisable to consult a doctor as soon as possible to clarify the cause.<br \/>\nIf a retinoblastoma (or another malignant disease) is actually present, a timely diagnosis is the best prerequisite for successful treatment of the disease.  <\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/details>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5e3d30d e-flex e-con-boxed e-con e-parent\" data-id=\"5e3d30d\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-55a8164 elementor-widget-divider--view-line elementor-invisible elementor-widget elementor-widget-divider\" data-id=\"55a8164\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-18ae961 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"18ae961\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Sources: Maria Yiallouros, editorial team kinderkrebsinfo.de<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2b131419 e-flex e-con-boxed e-con e-parent\" data-id=\"2b131419\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-55cea964 e-con-full e-flex e-con e-child\" data-id=\"55cea964\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2f9b7d elementor-invisible elementor-widget elementor-widget-image\" data-id=\"2f9b7d\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInLeft&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"450\" height=\"300\" src=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/05\/KAKS-Krankheitsbild-02.jpg\" class=\"attachment-large size-large wp-image-8186\" alt=\"\" srcset=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/05\/KAKS-Krankheitsbild-02.jpg 450w, https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/05\/KAKS-Krankheitsbild-02-300x200.jpg 300w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4b7a7c6c e-con-full e-flex e-con e-child\" data-id=\"4b7a7c6c\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-65df3bee elementor-absolute elementor-view-default elementor-invisible elementor-widget elementor-widget-icon\" data-id=\"65df3bee\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;,&quot;_animation&quot;:&quot;fadeInRight&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" height=\"140\" viewBox=\"0 0 151.192 140\" width=\"151.192\"><clipPath id=\"a\"><path d=\"m0 0h151.192v140h-151.192z\"><\/path><\/clipPath><clipPath id=\"b\"><path d=\"m0 0h74.797v68.922h-74.797z\"><\/path><\/clipPath><g clip-path=\"url(#a)\"><path d=\"m128.457 110.044c-15.867 20.913-34.295 29.956-58.457 29.956a70 70 0 1 1 19.972-137.108s13.771 3.784 22.984 15.292c0 0 7.659 8.213 13.346 10.219a26.335 26.335 0 0 0 8.53 1.418 26.267 26.267 0 0 0 16.348-5.674s1.27 54.276-22.723 85.9\" fill=\"#f80000\"><\/path><\/g><g clip-path=\"url(#b)\" transform=\"translate(33.441 36.34)\"><path d=\"m35.116 66.029.382.116c1.4.425 2.731.826 3.606 2.583a.345.345 0 0 0 .091.115.337.337 0 0 0 .221.079.345.345 0 0 0 .191-.057c.645-.424 1.252-.808 1.829-1.173 1.208-.764 2.251-1.424 3.249-2.193a59.577 59.577 0 0 0 9.735-9.229c3.8-4.594 7.727-9.344 11.426-14.316a85.76 85.76 0 0 0 5.955-9.6 24.222 24.222 0 0 0 2.911-9.9 22.825 22.825 0 0 0 -4-15.288c-3.45-4.936-8.043-7.341-13.639-7.156a23.986 23.986 0 0 0 -16.5 7.242 6.894 6.894 0 0 0 -.624.748 2.844 2.844 0 0 1 -1.217 1.1c-5.41-5.318-9.545-7.4-15.732-7.933-6.349-.547-11.489 1.514-15.277 6.125a44.2 44.2 0 0 0 -4.923 7.357 23.183 23.183 0 0 0 -1.83 17.719 44.3 44.3 0 0 0 7.659 15.118 52.978 52.978 0 0 0 26.487 18.543m-26.189-50.319a43.188 43.188 0 0 1 2.71-4.475 11.346 11.346 0 0 1 9.903-5.235q.784 0 1.609.081a18.327 18.327 0 0 1 13.431 7.45c.394.527.823 1.015 1.2 1.445.154.175.3.34.427.492a.349.349 0 0 0 .207.118 2.241 2.241 0 0 0 2.592-1.3c2.633-4.41 6.732-7.043 12.9-8.284a15.066 15.066 0 0 1 4.421-.111 8.44 8.44 0 0 1 5.958 3.444 15.028 15.028 0 0 1 3.132 8.242 19.059 19.059 0 0 1 -1.824 10.1 60.941 60.941 0 0 1 -3.9 7.027c-2.7 4.012-5.577 8-8.361 11.857l-.968 1.342c-2.073 2.875-4.218 5.773-6.291 8.576q-1.122 1.521-2.243 3.037c-.323.437-.658.865-1.013 1.318l-.357.457-2.913-1.211c-2.242-.931-4.379-1.819-6.511-2.72a47.043 47.043 0 0 1 -15.712-10.7 41.424 41.424 0 0 1 -9.7-15.554 18.835 18.835 0 0 1 1.3-15.4\" fill=\"#fff\"><\/path><\/g><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7889ca29 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"7889ca29\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>What is leukocoria?<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1f126da6 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"1f126da6\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Leukocoria means &#8216;white pupil&#8217; and occurs when the typical red pupillary reflex is absent, e.g. in photographs.<br \/>\nCauses can be retinoblastoma, cataracts, retinopathy of prematurity, retinal or choroidal coloboma and rare hereditary diseases.<br \/>\nImmediate clarification by an ophthalmologist is required.  <\/strong><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-60f3c5a7 elementor-widget elementor-widget-spacer\" data-id=\"60f3c5a7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e4ff7f9 e-flex e-con-boxed e-con e-parent\" data-id=\"e4ff7f9\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-c7fcfa2 e-con-full e-flex e-con e-child\" data-id=\"c7fcfa2\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-43679ac elementor-invisible elementor-widget elementor-widget-image\" data-id=\"43679ac\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInLeft&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"450\" height=\"300\" src=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/05\/KAKS-Krankheitsbild-01.jpg\" class=\"attachment-large size-large wp-image-8188\" alt=\"\" srcset=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/05\/KAKS-Krankheitsbild-01.jpg 450w, https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/05\/KAKS-Krankheitsbild-01-300x200.jpg 300w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f081f6e e-con-full e-flex e-con e-child\" data-id=\"f081f6e\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-99b4285 elementor-absolute elementor-view-default elementor-invisible elementor-widget elementor-widget-icon\" data-id=\"99b4285\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;,&quot;_animation&quot;:&quot;fadeInRight&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" height=\"140\" viewBox=\"0 0 151.192 140\" width=\"151.192\"><clipPath id=\"a\"><path d=\"m0 0h151.192v140h-151.192z\"><\/path><\/clipPath><clipPath id=\"b\"><path d=\"m0 0h74.797v68.922h-74.797z\"><\/path><\/clipPath><g clip-path=\"url(#a)\"><path d=\"m128.457 110.044c-15.867 20.913-34.295 29.956-58.457 29.956a70 70 0 1 1 19.972-137.108s13.771 3.784 22.984 15.292c0 0 7.659 8.213 13.346 10.219a26.335 26.335 0 0 0 8.53 1.418 26.267 26.267 0 0 0 16.348-5.674s1.27 54.276-22.723 85.9\" fill=\"#f80000\"><\/path><\/g><g clip-path=\"url(#b)\" transform=\"translate(33.441 36.34)\"><path d=\"m35.116 66.029.382.116c1.4.425 2.731.826 3.606 2.583a.345.345 0 0 0 .091.115.337.337 0 0 0 .221.079.345.345 0 0 0 .191-.057c.645-.424 1.252-.808 1.829-1.173 1.208-.764 2.251-1.424 3.249-2.193a59.577 59.577 0 0 0 9.735-9.229c3.8-4.594 7.727-9.344 11.426-14.316a85.76 85.76 0 0 0 5.955-9.6 24.222 24.222 0 0 0 2.911-9.9 22.825 22.825 0 0 0 -4-15.288c-3.45-4.936-8.043-7.341-13.639-7.156a23.986 23.986 0 0 0 -16.5 7.242 6.894 6.894 0 0 0 -.624.748 2.844 2.844 0 0 1 -1.217 1.1c-5.41-5.318-9.545-7.4-15.732-7.933-6.349-.547-11.489 1.514-15.277 6.125a44.2 44.2 0 0 0 -4.923 7.357 23.183 23.183 0 0 0 -1.83 17.719 44.3 44.3 0 0 0 7.659 15.118 52.978 52.978 0 0 0 26.487 18.543m-26.189-50.319a43.188 43.188 0 0 1 2.71-4.475 11.346 11.346 0 0 1 9.903-5.235q.784 0 1.609.081a18.327 18.327 0 0 1 13.431 7.45c.394.527.823 1.015 1.2 1.445.154.175.3.34.427.492a.349.349 0 0 0 .207.118 2.241 2.241 0 0 0 2.592-1.3c2.633-4.41 6.732-7.043 12.9-8.284a15.066 15.066 0 0 1 4.421-.111 8.44 8.44 0 0 1 5.958 3.444 15.028 15.028 0 0 1 3.132 8.242 19.059 19.059 0 0 1 -1.824 10.1 60.941 60.941 0 0 1 -3.9 7.027c-2.7 4.012-5.577 8-8.361 11.857l-.968 1.342c-2.073 2.875-4.218 5.773-6.291 8.576q-1.122 1.521-2.243 3.037c-.323.437-.658.865-1.013 1.318l-.357.457-2.913-1.211c-2.242-.931-4.379-1.819-6.511-2.72a47.043 47.043 0 0 1 -15.712-10.7 41.424 41.424 0 0 1 -9.7-15.554 18.835 18.835 0 0 1 1.3-15.4\" fill=\"#fff\"><\/path><\/g><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1c00e6e elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"1c00e6e\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Good to know<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0753190 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"0753190\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Children from families with a hereditary increased risk of retinoblastoma should receive regular ophthalmologic examinations, even without any recognizable complaints or symptoms.<br \/>\nThis enables early detection of the disease and the timely initiation of appropriate treatment measures. <\/strong><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9fc3d90 elementor-widget elementor-widget-spacer\" data-id=\"9fc3d90\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bebf4cb e-flex e-con-boxed e-con e-parent\" data-id=\"bebf4cb\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-27201d0 elementor-widget-divider--view-line elementor-invisible elementor-widget elementor-widget-divider\" data-id=\"27201d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d589ae1 e-flex e-con-boxed e-con e-parent\" data-id=\"d589ae1\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-5dc6e87 e-con-full e-flex e-con e-child\" data-id=\"5dc6e87\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-dc5484a elementor-invisible elementor-widget elementor-widget-counter\" data-id=\"dc5484a\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"counter.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-counter\">\n\t\t\t\t\t\t<div class=\"elementor-counter-number-wrapper\">\n\t\t\t\t<span class=\"elementor-counter-number-prefix\">1:<\/span>\n\t\t\t\t<span class=\"elementor-counter-number\" data-duration=\"5000\" data-to-value=\"20000\" data-from-value=\"0\" data-delimiter=\".\">0<\/span>\n\t\t\t\t<span class=\"elementor-counter-number-suffix\"><\/span>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-87afce0 elementor-widget elementor-widget-spacer\" data-id=\"87afce0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6ee5a46 elementor-widget-mobile_extra__width-initial elementor-widget-tablet__width-initial elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"6ee5a46\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Worldwide, around 1:20,000 children fall ill every year, regardless of their origin or gender.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-47323d5 e-con-full e-flex e-con e-child\" data-id=\"47323d5\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c99ad9c elementor-invisible elementor-widget elementor-widget-counter\" data-id=\"c99ad9c\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"counter.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-counter\">\n\t\t\t\t\t\t<div class=\"elementor-counter-number-wrapper\">\n\t\t\t\t<span class=\"elementor-counter-number-prefix\"><\/span>\n\t\t\t\t<span class=\"elementor-counter-number\" data-duration=\"5000\" data-to-value=\"95\" data-from-value=\"0\" data-delimiter=\".\">0<\/span>\n\t\t\t\t<span class=\"elementor-counter-number-suffix\">%<\/span>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6015f1d elementor-widget elementor-widget-spacer\" data-id=\"6015f1d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8baa744 elementor-widget-mobile_extra__width-initial elementor-widget-tablet__width-initial elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"8baa744\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>If detected early, 95% of children are cured in medically well-developed countries.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-49323d4 e-con-full e-flex e-con e-child\" data-id=\"49323d4\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0bfc3d9 elementor-invisible elementor-widget elementor-widget-counter\" data-id=\"0bfc3d9\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"counter.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-counter\">\n\t\t\t\t\t\t<div class=\"elementor-counter-number-wrapper\">\n\t\t\t\t<span class=\"elementor-counter-number-prefix\"><\/span>\n\t\t\t\t<span class=\"elementor-counter-number\" data-duration=\"5000\" data-to-value=\"80\" data-from-value=\"0\" data-delimiter=\".\">0<\/span>\n\t\t\t\t<span class=\"elementor-counter-number-suffix\">%<\/span>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e751f9f elementor-widget elementor-widget-spacer\" data-id=\"e751f9f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fb3483d elementor-widget-mobile_extra__width-initial elementor-widget-tablet__width-initial elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"fb3483d\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>In developing countries, up to 80% of children die because they are diagnosed too late.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4d74fc9 e-flex e-con-boxed e-con e-parent\" data-id=\"4d74fc9\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4770905 elementor-widget-divider--view-line elementor-invisible elementor-widget elementor-widget-divider\" data-id=\"4770905\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-172795d e-flex e-con-boxed e-con e-parent\" data-id=\"172795d\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-319acf3 e-con-full e-flex e-con e-child\" data-id=\"319acf3\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5e9b88f elementor-invisible elementor-widget elementor-widget-image\" data-id=\"5e9b88f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInLeft&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"450\" height=\"300\" src=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/05\/KAKS-Krankheitsbild-03.jpg\" class=\"attachment-large size-large wp-image-8190\" alt=\"\" srcset=\"https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/05\/KAKS-Krankheitsbild-03.jpg 450w, https:\/\/kinderaugenkrebsstiftung.de\/wp-content\/uploads\/2024\/05\/KAKS-Krankheitsbild-03-300x200.jpg 300w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-206cec9 e-con-full e-flex e-con e-child\" data-id=\"206cec9\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5ec1dc4 elementor-absolute elementor-view-default elementor-invisible elementor-widget elementor-widget-icon\" data-id=\"5ec1dc4\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;,&quot;_animation&quot;:&quot;fadeInRight&quot;,&quot;_animation_mobile&quot;:&quot;fadeIn&quot;,&quot;_animation_mobile_extra&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"icon.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-wrapper\">\n\t\t\t<div class=\"elementor-icon\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" height=\"140\" viewBox=\"0 0 151.192 140\" width=\"151.192\"><clipPath id=\"a\"><path d=\"m0 0h151.192v140h-151.192z\"><\/path><\/clipPath><clipPath id=\"b\"><path d=\"m0 0h74.797v68.922h-74.797z\"><\/path><\/clipPath><g clip-path=\"url(#a)\"><path d=\"m128.457 110.044c-15.867 20.913-34.295 29.956-58.457 29.956a70 70 0 1 1 19.972-137.108s13.771 3.784 22.984 15.292c0 0 7.659 8.213 13.346 10.219a26.335 26.335 0 0 0 8.53 1.418 26.267 26.267 0 0 0 16.348-5.674s1.27 54.276-22.723 85.9\" fill=\"#f80000\"><\/path><\/g><g clip-path=\"url(#b)\" transform=\"translate(33.441 36.34)\"><path d=\"m35.116 66.029.382.116c1.4.425 2.731.826 3.606 2.583a.345.345 0 0 0 .091.115.337.337 0 0 0 .221.079.345.345 0 0 0 .191-.057c.645-.424 1.252-.808 1.829-1.173 1.208-.764 2.251-1.424 3.249-2.193a59.577 59.577 0 0 0 9.735-9.229c3.8-4.594 7.727-9.344 11.426-14.316a85.76 85.76 0 0 0 5.955-9.6 24.222 24.222 0 0 0 2.911-9.9 22.825 22.825 0 0 0 -4-15.288c-3.45-4.936-8.043-7.341-13.639-7.156a23.986 23.986 0 0 0 -16.5 7.242 6.894 6.894 0 0 0 -.624.748 2.844 2.844 0 0 1 -1.217 1.1c-5.41-5.318-9.545-7.4-15.732-7.933-6.349-.547-11.489 1.514-15.277 6.125a44.2 44.2 0 0 0 -4.923 7.357 23.183 23.183 0 0 0 -1.83 17.719 44.3 44.3 0 0 0 7.659 15.118 52.978 52.978 0 0 0 26.487 18.543m-26.189-50.319a43.188 43.188 0 0 1 2.71-4.475 11.346 11.346 0 0 1 9.903-5.235q.784 0 1.609.081a18.327 18.327 0 0 1 13.431 7.45c.394.527.823 1.015 1.2 1.445.154.175.3.34.427.492a.349.349 0 0 0 .207.118 2.241 2.241 0 0 0 2.592-1.3c2.633-4.41 6.732-7.043 12.9-8.284a15.066 15.066 0 0 1 4.421-.111 8.44 8.44 0 0 1 5.958 3.444 15.028 15.028 0 0 1 3.132 8.242 19.059 19.059 0 0 1 -1.824 10.1 60.941 60.941 0 0 1 -3.9 7.027c-2.7 4.012-5.577 8-8.361 11.857l-.968 1.342c-2.073 2.875-4.218 5.773-6.291 8.576q-1.122 1.521-2.243 3.037c-.323.437-.658.865-1.013 1.318l-.357.457-2.913-1.211c-2.242-.931-4.379-1.819-6.511-2.72a47.043 47.043 0 0 1 -15.712-10.7 41.424 41.424 0 0 1 -9.7-15.554 18.835 18.835 0 0 1 1.3-15.4\" fill=\"#fff\"><\/path><\/g><\/svg>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4f1b086 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"4f1b086\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>We are here for you!<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1cdd0a1 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"1cdd0a1\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><b>Do you have any questions, suggestions or would you like to get to know our foundation better?  <\/b><\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-09467cb elementor-widget elementor-widget-spacer\" data-id=\"09467cb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ec8fab0 e-con-full e-flex e-con e-child\" data-id=\"ec8fab0\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7e0ee77 elementor-align-left elementor-invisible elementor-widget elementor-widget-button\" data-id=\"7e0ee77\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/kinderaugenkrebsstiftung.de\/en\/contact-us\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Contact us now<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5834c399 e-flex e-con-boxed e-con e-parent\" data-id=\"5834c399\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:&quot;yes&quot;,&quot;_ha_eqh_widget&quot;:[&quot;ha-infobox&quot;],&quot;_ha_eqh_disable_on_tablet&quot;:&quot;yes&quot;,&quot;_ha_eqh_to&quot;:&quot;widget&quot;,&quot;_ha_eqh_disable_on_mobile&quot;:&quot;yes&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5e3f1e1 elementor-widget elementor-widget-heading\" data-id=\"5e3f1e1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Further information<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-322df419 e-con-full e-flex e-con e-child\" data-id=\"322df419\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t<div class=\"elementor-element elementor-element-15fd3349 e-con-full e-flex e-con e-child\" data-id=\"15fd3349\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-58dfb24f ha-infobox-media-dir-top ha-has-bg-overlay elementor-invisible elementor-widget elementor-widget-ha-infobox happy-addon ha-infobox\" data-id=\"58dfb24f\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"ha-infobox.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n\t\t\n\t\t<div class=\"ha-infobox-body\">\n\t\t\t<h3 class=\"ha-infobox-title\">6 Warning signs<\/h3>\n\t\t\t\n\t\t\t<a class=\"ha-btn ha-btn--link\" href=\"https:\/\/kinderaugenkrebsstiftung.de\/en\/about-retinoblastoma\/warning-signs\/\"><span class=\"ha-btn-text\">Learn more<\/span><\/a>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2252e2ab e-con-full e-flex e-con e-child\" data-id=\"2252e2ab\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-339f7ae8 ha-infobox-media-dir-top ha-has-bg-overlay elementor-invisible elementor-widget elementor-widget-ha-infobox happy-addon ha-infobox\" data-id=\"339f7ae8\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"ha-infobox.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n\t\t\n\t\t<div class=\"ha-infobox-body\">\n\t\t\t<h3 class=\"ha-infobox-title\">Diagnosis<\/h3>\n\t\t\t\n\t\t\t<a class=\"ha-btn ha-btn--link\" href=\"https:\/\/kinderaugenkrebsstiftung.de\/en\/about-retinoblastoma\/diagnosis\/\"><span class=\"ha-btn-text\">Learn more<\/span><\/a>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-321099b e-con-full e-flex e-con e-child\" data-id=\"321099b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4b0259c ha-infobox-media-dir-top ha-has-bg-overlay elementor-invisible elementor-widget elementor-widget-ha-infobox happy-addon ha-infobox\" data-id=\"4b0259c\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeIn&quot;}\" data-widget_type=\"ha-infobox.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\n\t\t\n\t\t<div class=\"ha-infobox-body\">\n\t\t\t<h3 class=\"ha-infobox-title\">Treatment<\/h3>\n\t\t\t\n\t\t\t<a class=\"ha-btn ha-btn--link\" href=\"https:\/\/kinderaugenkrebsstiftung.de\/en\/about-retinoblastoma\/treatment\/\"><span class=\"ha-btn-text\">Learn more<\/span><\/a>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Definition Clinical picture Retinoblastoma is a rare cancer of the eye. It develops in the retina and occurs almost exclusively in children. A distinction is made between a hereditary and a non-hereditary form of the disease. In the first case, there is a predisposition for the development of this type of cancer, in the second [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":12285,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"uix_meta_title":"","uix_meta_description":"","uix_canonical_url":"","footnotes":""},"class_list":["post-12480","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/kinderaugenkrebsstiftung.de\/en\/wp-json\/wp\/v2\/pages\/12480","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kinderaugenkrebsstiftung.de\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/kinderaugenkrebsstiftung.de\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/kinderaugenkrebsstiftung.de\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kinderaugenkrebsstiftung.de\/en\/wp-json\/wp\/v2\/comments?post=12480"}],"version-history":[{"count":0,"href":"https:\/\/kinderaugenkrebsstiftung.de\/en\/wp-json\/wp\/v2\/pages\/12480\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/kinderaugenkrebsstiftung.de\/en\/wp-json\/wp\/v2\/pages\/12285"}],"wp:attachment":[{"href":"https:\/\/kinderaugenkrebsstiftung.de\/en\/wp-json\/wp\/v2\/media?parent=12480"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}